Sirtuins, Bioageing, and Cancer
The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins are heavily implicated in cell cycle, cell di...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/235754 |
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| author | D. McGuinness D. H. McGuinness J. A. McCaul P. G. Shiels |
| author_facet | D. McGuinness D. H. McGuinness J. A. McCaul P. G. Shiels |
| author_sort | D. McGuinness |
| collection | DOAJ |
| description | The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins are heavily implicated in cell cycle, cell division, transcription regulation, and metabolism, which places the various family members at critical junctures in cellular metabolism. Typically, Sirtuins have been implicated in the preservation of genomic stability and in the prolongation of lifespan though many of their target interactions remain unknown.
Sirtuins play key roles in tumourigenesis, as some have tumour-suppressor functions and others influence tumours through their control of the metabolic state of the cell. Their links to ageing have also highlighted involvement in various age-related and degenerative diseases. Here, we discuss the current understanding of the role of Sirtuins in age-related diseases while taking a closer look at their roles and functions in maintaining genomic stability and their influence on telomerase and telomere function. |
| format | Article |
| id | doaj-art-4d747d355bf24c19acbb5c0fb93dafe3 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-4d747d355bf24c19acbb5c0fb93dafe32025-02-03T06:48:29ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/235754235754Sirtuins, Bioageing, and CancerD. McGuinness0D. H. McGuinness1J. A. McCaul2P. G. Shiels3College of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow G11 6NT, Scotland, UKCollege of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow G11 6NT, Scotland, UKMaxillofacial and Head and Neck Unit, Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford BD5 0NA, UKCollege of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow G11 6NT, Scotland, UKThe Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins are heavily implicated in cell cycle, cell division, transcription regulation, and metabolism, which places the various family members at critical junctures in cellular metabolism. Typically, Sirtuins have been implicated in the preservation of genomic stability and in the prolongation of lifespan though many of their target interactions remain unknown. Sirtuins play key roles in tumourigenesis, as some have tumour-suppressor functions and others influence tumours through their control of the metabolic state of the cell. Their links to ageing have also highlighted involvement in various age-related and degenerative diseases. Here, we discuss the current understanding of the role of Sirtuins in age-related diseases while taking a closer look at their roles and functions in maintaining genomic stability and their influence on telomerase and telomere function.http://dx.doi.org/10.4061/2011/235754 |
| spellingShingle | D. McGuinness D. H. McGuinness J. A. McCaul P. G. Shiels Sirtuins, Bioageing, and Cancer Journal of Aging Research |
| title | Sirtuins, Bioageing, and Cancer |
| title_full | Sirtuins, Bioageing, and Cancer |
| title_fullStr | Sirtuins, Bioageing, and Cancer |
| title_full_unstemmed | Sirtuins, Bioageing, and Cancer |
| title_short | Sirtuins, Bioageing, and Cancer |
| title_sort | sirtuins bioageing and cancer |
| url | http://dx.doi.org/10.4061/2011/235754 |
| work_keys_str_mv | AT dmcguinness sirtuinsbioageingandcancer AT dhmcguinness sirtuinsbioageingandcancer AT jamccaul sirtuinsbioageingandcancer AT pgshiels sirtuinsbioageingandcancer |