Synthesis, in silico studies and in vitro cytotoxicity evaluation of novel posaconazole derivative as a ALK TK inhibitor

Synthesis, in silico studies and in vitro cytotoxicity evaluation of novel posaconazole derivative as a ALK TK inhibitor

Oncology research progresses, yet cancer remains the largest medical need. The use of a medication with an accessible lead molecule shows great potential for long-term cancer therapy. It may help target cancer therapy and drug resistance. This work uses FDA-approved, clinically proven compounds to b...

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Bibliographic Details
Main Authors: Rahul D. Jawarkar, Praveen Sharma, Sachin Jain, Umang Shah, Magdi EA Zaki, Sami A Al-Hussain, Suraj Mali, Chin-Hung Lai, Vijay H. Masand, Vivek T Humne
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Taibah University for Science
Subjects:
In-silico
ALK TK
molecular docking
A549 cell line
MD simulation
MMGBSA
Online Access:https://www.tandfonline.com/doi/10.1080/16583655.2024.2336674
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