Role of alpha-1 antitrypsin in Bruch’s membrane integrity

Role of alpha-1 antitrypsin in Bruch’s membrane integrity

Abstract Alpha-1 antitrypsin (AAT) is a serine protease inhibitor that plays a crucial role in maintaining extracellular matrix integrity. Studies suggest that AAT augmentation therapy may benefit multiple eye diseases, including age-related macular degeneration (AMD). However, the function of endog...

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Bibliographic Details
Main Authors: Shun-Yun Cheng, Delaney Giguere, Ilana Silverstein, Adrienne Conza, Johanna M. Seddon, San Kim, Takeshi Iwata, Christian Mueller, Claudio Punzo
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Alpha-1 antitrypsin
Age-related macular degeneration
AAT
A1AT
AMD risk alleles
Bruch’s membrane
Online Access:https://doi.org/10.1038/s41598-025-96570-x
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https://doi.org/10.1038/s41598-025-96570-x

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