In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve
Abstract The waveform of ventricular action potential (AP) is a key determinant of the cardiac cycle, a marker of beating pathophysiology, and a target for anti‐arrhythmic drug design. The information contained in the waveform, though, is limited to the actual dynamics of the AP under consideration....
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Wiley
2024-11-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70085 |
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| author | Massimiliano Zaniboni |
| author_facet | Massimiliano Zaniboni |
| author_sort | Massimiliano Zaniboni |
| collection | DOAJ |
| description | Abstract The waveform of ventricular action potential (AP) is a key determinant of the cardiac cycle, a marker of beating pathophysiology, and a target for anti‐arrhythmic drug design. The information contained in the waveform, though, is limited to the actual dynamics of the AP under consideration. By measuring quasi‐instantaneous current–voltage relationships during repolarization, I propose a three‐dimensional representation of the ventricular AP which includes potential dynamic responses that the beat can show when electrically perturbed. This representation is described in the case of a numerically reconstructed ventricular AP, but it can be, at least partially, derived in real cardiomyocytes. Simulation allows to disclose the potentialities and the limitations of the approach, that can be extended to any non‐cardiac AP. By reporting, at any AP time, the ion current available within the physiological membrane potential range at that time, the representation makes all together available: (1) refractory period, (2) thresholds for eliciting full or calcium‐driven APs, (3) threshold for all‐or‐none repolarization, (4) membrane resistance during repolarization, (5) the safety of membrane repolarization. It provides further evidence of a negative membrane resistance during the late phase of ventricular AP and a quantitative estimate of repolarization reserve (RR), key determinants of repolarization dynamics. |
| format | Article |
| id | doaj-art-4d3633673adc4b1d9f6767c28317e889 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-4d3633673adc4b1d9f6767c28317e8892025-01-25T06:41:00ZengWileyPhysiological Reports2051-817X2024-11-011221n/an/a10.14814/phy2.70085In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserveMassimiliano Zaniboni0Department of Chemistry, Life Sciences and Environmental Sustainability University of Parma (Italy) ‐ Parco Area Delle Scienze Parma ItalyAbstract The waveform of ventricular action potential (AP) is a key determinant of the cardiac cycle, a marker of beating pathophysiology, and a target for anti‐arrhythmic drug design. The information contained in the waveform, though, is limited to the actual dynamics of the AP under consideration. By measuring quasi‐instantaneous current–voltage relationships during repolarization, I propose a three‐dimensional representation of the ventricular AP which includes potential dynamic responses that the beat can show when electrically perturbed. This representation is described in the case of a numerically reconstructed ventricular AP, but it can be, at least partially, derived in real cardiomyocytes. Simulation allows to disclose the potentialities and the limitations of the approach, that can be extended to any non‐cardiac AP. By reporting, at any AP time, the ion current available within the physiological membrane potential range at that time, the representation makes all together available: (1) refractory period, (2) thresholds for eliciting full or calcium‐driven APs, (3) threshold for all‐or‐none repolarization, (4) membrane resistance during repolarization, (5) the safety of membrane repolarization. It provides further evidence of a negative membrane resistance during the late phase of ventricular AP and a quantitative estimate of repolarization reserve (RR), key determinants of repolarization dynamics.https://doi.org/10.14814/phy2.70085cardiac action potentialmembrane resistance during the action potentialquasi‐instantaneous IV curvesreserve of repolarizationthreshold for all‐or‐none‐repolarizationthreshold for excitation |
| spellingShingle | Massimiliano Zaniboni In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve Physiological Reports cardiac action potential membrane resistance during the action potential quasi‐instantaneous IV curves reserve of repolarization threshold for all‐or‐none‐repolarization threshold for excitation |
| title | In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve |
| title_full | In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve |
| title_fullStr | In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve |
| title_full_unstemmed | In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve |
| title_short | In silico analysis of ventricular action potential with a current–voltage‐time representation: Thresholds, membrane resistance, repolarization reserve |
| title_sort | in silico analysis of ventricular action potential with a current voltage time representation thresholds membrane resistance repolarization reserve |
| topic | cardiac action potential membrane resistance during the action potential quasi‐instantaneous IV curves reserve of repolarization threshold for all‐or‐none‐repolarization threshold for excitation |
| url | https://doi.org/10.14814/phy2.70085 |
| work_keys_str_mv | AT massimilianozaniboni insilicoanalysisofventricularactionpotentialwithacurrentvoltagetimerepresentationthresholdsmembraneresistancerepolarizationreserve |