The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning
Drowning is an acute respiratory failure as a result from immersion or submersion of the airways in a liquid medium (predominantly water). Inhalation of water causes severe lung damage due to the destruction of pulmonary surfactant, resulting in decreased lung elasticity, alveolar collapse, alterati...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2020/9270791 |
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| author | Mario Pezzi Francesco Givigliano Ottorino Perrone Annamaria Scozzafava Pietro Maglio Patrizia Casella Anna Maria Giglio Mario Verre Carlo Pietro Voci |
| author_facet | Mario Pezzi Francesco Givigliano Ottorino Perrone Annamaria Scozzafava Pietro Maglio Patrizia Casella Anna Maria Giglio Mario Verre Carlo Pietro Voci |
| author_sort | Mario Pezzi |
| collection | DOAJ |
| description | Drowning is an acute respiratory failure as a result from immersion or submersion of the airways in a liquid medium (predominantly water). Inhalation of water causes severe lung damage due to the destruction of pulmonary surfactant, resulting in decreased lung elasticity, alveolar collapse, alteration of ventilation-perfusion ratio, intrapulmonary blood shunting, hypoxia, acute lung injury, and Acute Respiratory Distress Syndrome (ARDS). Poractant alfa (Curosurf®), a natural surfactant effective in the treatment of newborn respiratory distress, has been used in various forms of ARDS, but in drowning syndromes, experience is still poor. We describe a series of nine clinical cases of drowning, six adults and three children, treated in our Intensive Care Unit (ICU) with endobronchial administration of poractant alfa. After 24 and 48 hours of administration in all cases, there was an improvement in arterial blood gas analysis (ABG) parameters and imaging. All patients were discharged without clinical consequences. |
| format | Article |
| id | doaj-art-4d21ac5e43d44c45a0fd92992dfd24fc |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-4d21ac5e43d44c45a0fd92992dfd24fc2025-02-03T06:45:49ZengWileyCase Reports in Critical Care2090-64202090-64392020-01-01202010.1155/2020/92707919270791The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by DrowningMario Pezzi0Francesco Givigliano1Ottorino Perrone2Annamaria Scozzafava3Pietro Maglio4Patrizia Casella5Anna Maria Giglio6Mario Verre7Carlo Pietro Voci8Anesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyAnesthesia and Intensive Care Department, University Department of Thoracic Surgery General Hospital “Pugliese-Ciaccio”, Catanzaro, ItalyDrowning is an acute respiratory failure as a result from immersion or submersion of the airways in a liquid medium (predominantly water). Inhalation of water causes severe lung damage due to the destruction of pulmonary surfactant, resulting in decreased lung elasticity, alveolar collapse, alteration of ventilation-perfusion ratio, intrapulmonary blood shunting, hypoxia, acute lung injury, and Acute Respiratory Distress Syndrome (ARDS). Poractant alfa (Curosurf®), a natural surfactant effective in the treatment of newborn respiratory distress, has been used in various forms of ARDS, but in drowning syndromes, experience is still poor. We describe a series of nine clinical cases of drowning, six adults and three children, treated in our Intensive Care Unit (ICU) with endobronchial administration of poractant alfa. After 24 and 48 hours of administration in all cases, there was an improvement in arterial blood gas analysis (ABG) parameters and imaging. All patients were discharged without clinical consequences.http://dx.doi.org/10.1155/2020/9270791 |
| spellingShingle | Mario Pezzi Francesco Givigliano Ottorino Perrone Annamaria Scozzafava Pietro Maglio Patrizia Casella Anna Maria Giglio Mario Verre Carlo Pietro Voci The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning Case Reports in Critical Care |
| title | The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning |
| title_full | The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning |
| title_fullStr | The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning |
| title_full_unstemmed | The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning |
| title_short | The Use of Exogenous Lung Surfactant (Poractant Alfa) in Acute Respiratory Failure by Drowning |
| title_sort | use of exogenous lung surfactant poractant alfa in acute respiratory failure by drowning |
| url | http://dx.doi.org/10.1155/2020/9270791 |
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