Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro
Mesenchymal stem cells (MSCs) are heterogeneous multipotent stem cells that are involved in the development of mesenchyme-derived evolving structures and organs during ontogeny. In the adult organism, reservoirs of MSCs can be found in almost all tissues where MSCs contribute to the maintenance of o...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/6726185 |
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| author | Jennifer Steens Diana Klein |
| author_facet | Jennifer Steens Diana Klein |
| author_sort | Jennifer Steens |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are heterogeneous multipotent stem cells that are involved in the development of mesenchyme-derived evolving structures and organs during ontogeny. In the adult organism, reservoirs of MSCs can be found in almost all tissues where MSCs contribute to the maintenance of organ integrity. The use of these different MSCs for cell-based therapies has been extensively studied over the past years, which highlights the use of MSCs as a promising option for the treatment of various diseases including autoimmune and cardiovascular disorders. However, the proportion of MSCs contained in primary isolates of adult tissue biopsies is rather low and, thus, vigorous ex vivo expansion is needed especially for therapies that may require extensive and repetitive cell substitution. Therefore, more easily and accessible sources of MSCs are needed. This review summarizes the current knowledge of the different strategies to generate human MSCs in vitro as an alternative method for their applications in regenerative therapy. |
| format | Article |
| id | doaj-art-4d085c60ccad42578ff7cf595696fe9d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4d085c60ccad42578ff7cf595696fe9d2025-02-03T01:10:32ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/67261856726185Current Strategies to Generate Human Mesenchymal Stem Cells In VitroJennifer Steens0Diana Klein1Institute for Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, GermanyInstitute for Cell Biology (Cancer Research), University Hospital Essen, University of Duisburg-Essen, Essen, GermanyMesenchymal stem cells (MSCs) are heterogeneous multipotent stem cells that are involved in the development of mesenchyme-derived evolving structures and organs during ontogeny. In the adult organism, reservoirs of MSCs can be found in almost all tissues where MSCs contribute to the maintenance of organ integrity. The use of these different MSCs for cell-based therapies has been extensively studied over the past years, which highlights the use of MSCs as a promising option for the treatment of various diseases including autoimmune and cardiovascular disorders. However, the proportion of MSCs contained in primary isolates of adult tissue biopsies is rather low and, thus, vigorous ex vivo expansion is needed especially for therapies that may require extensive and repetitive cell substitution. Therefore, more easily and accessible sources of MSCs are needed. This review summarizes the current knowledge of the different strategies to generate human MSCs in vitro as an alternative method for their applications in regenerative therapy.http://dx.doi.org/10.1155/2018/6726185 |
| spellingShingle | Jennifer Steens Diana Klein Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro Stem Cells International |
| title | Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro |
| title_full | Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro |
| title_fullStr | Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro |
| title_full_unstemmed | Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro |
| title_short | Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro |
| title_sort | current strategies to generate human mesenchymal stem cells in vitro |
| url | http://dx.doi.org/10.1155/2018/6726185 |
| work_keys_str_mv | AT jennifersteens currentstrategiestogeneratehumanmesenchymalstemcellsinvitro AT dianaklein currentstrategiestogeneratehumanmesenchymalstemcellsinvitro |