Organelles Ca2+ redistribution contributes to cadmium-induced EMT of renal cancer cells through p-cPLA2-mediated arachidonic acid release

Cadmium ion (Cd2+) is a non-essential metal that can increase cancer risk, including potentially renal cell carcinoma (RCC), though this link is not definitive. Cd2+ exposure impairs fatty acid metabolism in the kidneys, particularly affecting arachidonic acid (AA) levels, which are crucial for heal...

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Bibliographic Details
Main Authors: Jie Gu, Jiacheng Ruan, Chuanzhi Guo, Zehua Li, Huilin Fu, Yimin Xie, Hebing Xie, Xun Gong, Haifeng Shi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Ecotoxicology and Environmental Safety
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Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325006530
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