The impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors

The impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors

Abstract The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor cell invasion, metastasis, drug resistance, and recurrence. So, a be...

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Main Authors: Mahsa Liaghat, Saeid Ferdousmakan, Seyedeh Haniyeh Mortazavi, Sheida Yahyazadeh, Asrin Irani, Sara Banihashemi, Fatemeh Sadat Seyedi Asl, Abdullatif Akbari, Farnoosh Farzam, Fatemeh Aziziyan, Maryam Bakhtiyari, Mohammad Javad Arghavani, Hamidreza Zalpoor, Mohsen Nabi-Afjadi
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
EMT
Solid tumors
Metabolic profile
Chemotherapy resistance
Metastasis
Tumor recurrence
Online Access:https://doi.org/10.1186/s12964-024-01957-4
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