Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer’s disease continuum

Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer’s disease continuum

Abstract Background Gut microbiota dysbiosis is linked to Alzheimer’s disease (AD), but our understanding of the molecular and neuropathological bases underlying such association remains fragmentary. Methods Using 16S rDNA amplicon sequencing, untargeted metabolomics, and multi-modal magnetic resona...

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Bibliographic Details
Main Authors: Han Zhao, Xia Zhou, Yu Song, Wenming Zhao, Zhongwu Sun, Jiajia Zhu, Yongqiang Yu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Gut microbiome
Fecal metabolome
Neuroimaging
Cognition
Online Access:https://doi.org/10.1186/s13195-025-01683-0
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