CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer

CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer

Abstract Chloride intracellular channels (CLICs) are a family of six evolutionarily conserved proteins with diverse functions. Previously, we identified CLIC2, as the fifth-ranked master regulator associated with diffuse-type gastric cancer (dGC) showing increased expression in tumors. Here we used...

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Main Authors: Viviana Longo, Pellegrino Mazzone, Giovanni Calice, Pietro Zoppoli, Giuseppina Di Paola, Giuseppe Cesta, Margherita Luongo, Claudia Sabato, Sabino Russi, Simona Laurino, Tiziana Notarangelo, Giuseppe Patitucci, Chiara Balzamo, Valeria Lucci, Elena Amendola, Giuseppina Amodio, Paolo Remondelli, Valentina Pagliara, Maria Rita Milone, Roberta Guadagno, Cristofaro De Stefano, Ferdinando De Vita, Geppino Falco, Francesco Albano
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Biology Direct
Subjects:
Gastric microenvironment
Tumor microenvironment
Gastric cancer
Clic2
Macrophages
Differentiation
Online Access:https://doi.org/10.1186/s13062-025-00666-3
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https://doi.org/10.1186/s13062-025-00666-3

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