Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells
Abstract Polyploidy is a common outcome of chemotherapies, but there is conflicting evidence as to whether polyploidy is an adverse, benign or even favourable outcome. We show Aurora B kinase inhibitors efficiently promote polyploidy in many cell types, resulting in the cell cycle exit in RB and p53...
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Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2025-01-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-024-07329-7 |
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