tPA‐GFP is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells

tPA‐GFP is a reliable probe for detecting compound exocytosis in human pancreatic β‐cells

Abstract Pancreatic β‐cells secrete insulin stored in large dense core vesicles (LDCV) by fusion of vesicle and plasma membrane during a process called insulin exocytosis. Insulin secretion is biphasic with a fast first phase and a sustained second phase. Previous studies have pointed out that exocy...

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Bibliographic Details
Main Authors: Aishwarya A. Makam, Shruti Sharma, Prajwal Nagle, Nandhini M. Sundaram, Vidya Mangala Prasad, Nikhil R. Gandasi
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:FASEB BioAdvances
Subjects:
exocytosis
insulin granules
large dense core vesicles
total internal reflection fluorescence microscopy
Online Access:https://doi.org/10.1096/fba.2024-00131
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