Glycine rich proteins of ticks: more than a cement component
Glycine-rich proteins (GRPs) are arbitrarily defined as those containing 20% or more glycine residues and constitute a superfamily divided into subfamilies based on their structure and/or function. GRPs have been identified in a diverse array of organisms and have been shown to possess a number of d...
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| Format: | Article |
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Cambridge University Press
2024-08-01
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| Series: | Parasitology |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0031182024001410/type/journal_article |
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| author | Renata Perotto de Souza Mariana Vieira Dalla Valentina Bruna Ferreira Leal Sílvia Dias Oliveira Carlos Alexandre Sanchez Ferreira Ala Tabor |
| author_facet | Renata Perotto de Souza Mariana Vieira Dalla Valentina Bruna Ferreira Leal Sílvia Dias Oliveira Carlos Alexandre Sanchez Ferreira Ala Tabor |
| author_sort | Renata Perotto de Souza |
| collection | DOAJ |
| description | Glycine-rich proteins (GRPs) are arbitrarily defined as those containing 20% or more glycine residues and constitute a superfamily divided into subfamilies based on their structure and/or function. GRPs have been identified in a diverse array of organisms and have been shown to possess a number of distinctive biological characteristics, including nucleic acid binding, adhesive glue-like properties, antimicrobial activity, involvement in the stress response and in the formation of cuticle components. In ticks, their expression has been described and studied mainly in the salivary glands, and their primary function is usually associated with cement formation and/or structure. Conversely, several GRPs are present in all tick developmental stages, and the expression of many GRP genes is modulated by physiological processes and immune challenges, such as feeding and pathogen infection. Considering that some tick GRPs appear to play essential roles in the tick life cycle, they have been evaluated as immune targets, with a focus on their potential application in vaccine development. This review highlights the roles that tick GRPs may perform beyond the formation and maintenance of the cement scaffold, including structural characterization, locations and functional relevance, hypothetical functions, and their potential use in anti-tick vaccine development. |
| format | Article |
| id | doaj-art-4cb6f7707be249a0b23b7f25e1ec3a8c |
| institution | Kabale University |
| issn | 0031-1820 1469-8161 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Parasitology |
| spelling | doaj-art-4cb6f7707be249a0b23b7f25e1ec3a8c2025-01-23T07:11:40ZengCambridge University PressParasitology0031-18201469-81612024-08-011511063107310.1017/S0031182024001410Glycine rich proteins of ticks: more than a cement componentRenata Perotto de Souza0https://orcid.org/0000-0002-3354-4181Mariana Vieira Dalla Valentina1Bruna Ferreira Leal2Sílvia Dias Oliveira3Carlos Alexandre Sanchez Ferreira4https://orcid.org/0000-0002-3727-5097Ala TaborLaboratório de Imunologia e Microbiologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil Programa de Pós-graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, BrazilLaboratório de Imunologia e Microbiologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, BrazilLaboratório Central, Centro Estadual de Vigilância em Saúde da Secretaria de Saúde do Governo do Estado do Rio Grande do Sul (LACEN/SES-RS), Porto Alegre, RS, BrazilLaboratório de Imunologia e Microbiologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil Programa de Pós-graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, BrazilLaboratório de Imunologia e Microbiologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil Programa de Pós-graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, BrazilGlycine-rich proteins (GRPs) are arbitrarily defined as those containing 20% or more glycine residues and constitute a superfamily divided into subfamilies based on their structure and/or function. GRPs have been identified in a diverse array of organisms and have been shown to possess a number of distinctive biological characteristics, including nucleic acid binding, adhesive glue-like properties, antimicrobial activity, involvement in the stress response and in the formation of cuticle components. In ticks, their expression has been described and studied mainly in the salivary glands, and their primary function is usually associated with cement formation and/or structure. Conversely, several GRPs are present in all tick developmental stages, and the expression of many GRP genes is modulated by physiological processes and immune challenges, such as feeding and pathogen infection. Considering that some tick GRPs appear to play essential roles in the tick life cycle, they have been evaluated as immune targets, with a focus on their potential application in vaccine development. This review highlights the roles that tick GRPs may perform beyond the formation and maintenance of the cement scaffold, including structural characterization, locations and functional relevance, hypothetical functions, and their potential use in anti-tick vaccine development.https://www.cambridge.org/core/product/identifier/S0031182024001410/type/journal_articleTick salivary proteinstick-host relationshipvaccine |
| spellingShingle | Renata Perotto de Souza Mariana Vieira Dalla Valentina Bruna Ferreira Leal Sílvia Dias Oliveira Carlos Alexandre Sanchez Ferreira Ala Tabor Glycine rich proteins of ticks: more than a cement component Parasitology Tick salivary proteins tick-host relationship vaccine |
| title | Glycine rich proteins of ticks: more than a cement component |
| title_full | Glycine rich proteins of ticks: more than a cement component |
| title_fullStr | Glycine rich proteins of ticks: more than a cement component |
| title_full_unstemmed | Glycine rich proteins of ticks: more than a cement component |
| title_short | Glycine rich proteins of ticks: more than a cement component |
| title_sort | glycine rich proteins of ticks more than a cement component |
| topic | Tick salivary proteins tick-host relationship vaccine |
| url | https://www.cambridge.org/core/product/identifier/S0031182024001410/type/journal_article |
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