miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ
In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p cou...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6661828 |
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| _version_ | 1832547632328736768 |
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| author | Xuehui Wang Zhilu Yao Lin Fang |
| author_facet | Xuehui Wang Zhilu Yao Lin Fang |
| author_sort | Xuehui Wang |
| collection | DOAJ |
| description | In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target. |
| format | Article |
| id | doaj-art-4c89f2ca3ede44f99cdf31f638ddab1f |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-4c89f2ca3ede44f99cdf31f638ddab1f2025-02-03T06:43:49ZengWileyPPAR Research1687-47571687-47652021-01-01202110.1155/2021/66618286661828miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγXuehui Wang0Zhilu Yao1Lin Fang2Department of Thyroid and Breast Surgery, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Thyroid and Breast Surgery, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Thyroid and Breast Surgery, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaIn this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target.http://dx.doi.org/10.1155/2021/6661828 |
| spellingShingle | Xuehui Wang Zhilu Yao Lin Fang miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ PPAR Research |
| title | miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ |
| title_full | miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ |
| title_fullStr | miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ |
| title_full_unstemmed | miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ |
| title_short | miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ |
| title_sort | mir 22 3p pgc1β suppresses breast cancer cell tumorigenesis via pparγ |
| url | http://dx.doi.org/10.1155/2021/6661828 |
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