Development and Validation of AAV-Mediated Liver, Liver-VAT, and Liver-Brain SORT and Therapeutic Regulation of FASN in Hepatic De Novo Lipogenesis

Development and Validation of AAV-Mediated Liver, Liver-VAT, and Liver-Brain SORT and Therapeutic Regulation of FASN in Hepatic De Novo Lipogenesis

Hepatic lipogenesis combined with elevated endoplasmic reticulum (ER) stress is central to non-alcoholic steatohepatitis (NASH). However, the therapeutic targeting of key molecules is considerably less accomplished. Adeno-associated virus (AAV)-mediated gene therapies offer a new solution for variou...

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Main Authors: Ratulananda Bhadury, Mohammad Athar, Pooja Mishra, Chayanika Gogoi, Shubham Sharma, Devram S. Ghorpade
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
adeno-associated virus (AAV)
Selective ORgan Targeting (SORT)
cysteine-rich with EGF-like domain 2 (CRELD2)
fatty acid synthase (FASN)
NASH
Online Access:https://www.mdpi.com/2073-4409/14/5/372
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