Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities

Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities

Cancer cell spheroids autonomously form in the ascites fluid and are considered a conduit for epithelial ovarian cancer metastasis within the peritoneal cavity. Spheroids are homotypic, avascular 3D structures that acquire resistance to anoikis to remain viable after cellular detachment. We used in...

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Bibliographic Details
Main Authors: Bart Kolendowski, Sylvia Cheng, Yudith Ramos Valdes, Trevor G. Shepherd, Gabriel E. DiMattia
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
clear cell
ovarian
cancer
cell line
G2/M
spheroid
Online Access:https://www.mdpi.com/2073-4409/14/11/785
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