Are There Mutator Polymerases?
DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. Some of these...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2003.32 |
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| _version_ | 1832547567549808640 |
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| author | Miguel Garcia-Diaz Jose F. Ruiz Raquel Juarez Gloria Terrados Luis Blanco |
| author_facet | Miguel Garcia-Diaz Jose F. Ruiz Raquel Juarez Gloria Terrados Luis Blanco |
| author_sort | Miguel Garcia-Diaz |
| collection | DOAJ |
| description | DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. Some of these polymerases have a very low fidelity and have been suggested to play mutator roles in different processes, like translesion synthesis or somatic hypermutation. The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed. |
| format | Article |
| id | doaj-art-4c3b8e81e0024b0696dc804e08739cd5 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4c3b8e81e0024b0696dc804e08739cd52025-02-03T06:44:17ZengWileyThe Scientific World Journal1537-744X2003-01-01342243110.1100/tsw.2003.32Are There Mutator Polymerases?Miguel Garcia-Diaz0Jose F. Ruiz1Raquel Juarez2Gloria Terrados3Luis Blanco4Centro de Biolog�a Molecular Severo Ochoa (CSIC-UAM). Universidad Aut�noma, 28049 Madrid, SpainCentro de Biolog�a Molecular Severo Ochoa (CSIC-UAM). Universidad Aut�noma, 28049 Madrid, SpainCentro de Biolog�a Molecular Severo Ochoa (CSIC-UAM). Universidad Aut�noma, 28049 Madrid, SpainCentro de Biolog�a Molecular Severo Ochoa (CSIC-UAM). Universidad Aut�noma, 28049 Madrid, SpainCentro de Biolog�a Molecular Severo Ochoa (CSIC-UAM). Universidad Aut�noma, 28049 Madrid, SpainDNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. Some of these polymerases have a very low fidelity and have been suggested to play mutator roles in different processes, like translesion synthesis or somatic hypermutation. The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed.http://dx.doi.org/10.1100/tsw.2003.32 |
| spellingShingle | Miguel Garcia-Diaz Jose F. Ruiz Raquel Juarez Gloria Terrados Luis Blanco Are There Mutator Polymerases? The Scientific World Journal |
| title | Are There Mutator Polymerases? |
| title_full | Are There Mutator Polymerases? |
| title_fullStr | Are There Mutator Polymerases? |
| title_full_unstemmed | Are There Mutator Polymerases? |
| title_short | Are There Mutator Polymerases? |
| title_sort | are there mutator polymerases |
| url | http://dx.doi.org/10.1100/tsw.2003.32 |
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