Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy

Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy

Abstract Immunotherapy employing natural killer (NK) cells has emerged as a transformative approach to treating hematological malignancies. The reprogramming of NK cells by incorporating a chimeric antigen receptor (CAR) equipped with potent signaling domains has demonstrated efficacy in enhancing N...

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Bibliographic Details
Main Authors: Ali Moazzeni, Maryam Kheirandish, Gholamreza Khamisipour, Fatemeh Rahbarizadeh, Ali Akbar Pourfathollah
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Natural killer (NK) cell
Leukoreduction filters (LRF)
Healthy donor
Chimeric antigen receptor (CAR)
Online Access:https://doi.org/10.1038/s41598-025-97584-1
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https://doi.org/10.1038/s41598-025-97584-1

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