Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients
Background. Nicorandil in reducing contrast-induced nephropathy (CIN) following elective percutaneous coronary intervention (PCI) is an inconsistent practice. This article aims to evaluate the efficacy and safety of nicorandil in preventing CIN after elective PCI. Methods. This is a pooled analysis...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2020/4527816 |
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| author | Bin Yi Shaoyan Mo Yumei Jiang Dingwu Yi Jinwen Luo Xiang Chen Jian Rong |
| author_facet | Bin Yi Shaoyan Mo Yumei Jiang Dingwu Yi Jinwen Luo Xiang Chen Jian Rong |
| author_sort | Bin Yi |
| collection | DOAJ |
| description | Background. Nicorandil in reducing contrast-induced nephropathy (CIN) following elective percutaneous coronary intervention (PCI) is an inconsistent practice. This article aims to evaluate the efficacy and safety of nicorandil in preventing CIN after elective PCI. Methods. This is a pooled analysis of patients treated with elective PCI. The primary outcome was the incidence of CIN. The secondary outcomes were major adverse events, including mortality, heart failure, recurrent myocardial infarction, stroke, and renal replacement therapy. Results. A total of 1229 patients were recruited in our study. With statistical significance, nicorandil lowered the risk of CIN (odds ratio = 0.26; 95% confidence interval = 0.16–0.44; P<0.00001; I2 = 0%) in patients who underwent elective PCI. In addition, no significant differences were observed in the incidence of mortality, heart failure, recurrent myocardial infarction, stroke, and renal replacement therapy between the two groups (P>0.05). Conclusions. Our article indicated that nicorandil could prevent CIN without increasing the major adverse events. Furthermore, sufficiently powered and randomized clinical studies are still needed in order to determine the role of nicorandil in preventing CIN after elective PCI. |
| format | Article |
| id | doaj-art-4c25b43fee6f4bc4af547ec033e59634 |
| institution | Kabale University |
| issn | 0896-4327 1540-8183 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj-art-4c25b43fee6f4bc4af547ec033e596342025-02-03T05:53:52ZengWileyJournal of Interventional Cardiology0896-43271540-81832020-01-01202010.1155/2020/45278164527816Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 PatientsBin Yi0Shaoyan Mo1Yumei Jiang2Dingwu Yi3Jinwen Luo4Xiang Chen5Jian Rong6Department of Cardiothoracic Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Extracorporeal Circulation, Heart Center, The First Affiliated Hospital, Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, ChinaDepartment of Extracorporeal Circulation, Heart Center, The First Affiliated Hospital, Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, ChinaDepartment of Cardiac Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiothoracic Surgery, Hunan Children’s Hospital, Changsha, ChinaDepartment of Anesthesiology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Extracorporeal Circulation, Heart Center, The First Affiliated Hospital, Sun Yat-Sen University, Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, ChinaBackground. Nicorandil in reducing contrast-induced nephropathy (CIN) following elective percutaneous coronary intervention (PCI) is an inconsistent practice. This article aims to evaluate the efficacy and safety of nicorandil in preventing CIN after elective PCI. Methods. This is a pooled analysis of patients treated with elective PCI. The primary outcome was the incidence of CIN. The secondary outcomes were major adverse events, including mortality, heart failure, recurrent myocardial infarction, stroke, and renal replacement therapy. Results. A total of 1229 patients were recruited in our study. With statistical significance, nicorandil lowered the risk of CIN (odds ratio = 0.26; 95% confidence interval = 0.16–0.44; P<0.00001; I2 = 0%) in patients who underwent elective PCI. In addition, no significant differences were observed in the incidence of mortality, heart failure, recurrent myocardial infarction, stroke, and renal replacement therapy between the two groups (P>0.05). Conclusions. Our article indicated that nicorandil could prevent CIN without increasing the major adverse events. Furthermore, sufficiently powered and randomized clinical studies are still needed in order to determine the role of nicorandil in preventing CIN after elective PCI.http://dx.doi.org/10.1155/2020/4527816 |
| spellingShingle | Bin Yi Shaoyan Mo Yumei Jiang Dingwu Yi Jinwen Luo Xiang Chen Jian Rong Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients Journal of Interventional Cardiology |
| title | Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients |
| title_full | Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients |
| title_fullStr | Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients |
| title_full_unstemmed | Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients |
| title_short | Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients |
| title_sort | efficacy and safety of nicorandil in preventing contrast induced nephropathy after elective percutaneous coronary intervention a pooled analysis of 1229 patients |
| url | http://dx.doi.org/10.1155/2020/4527816 |
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