AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer’s disease

AP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer’s disease

Abstract Background Dysregulation retrograde axonal transport in neurons results in autophagosome accumulation, enhancing amyloid β (Aβ) production and accelerating Alzheimer’s disease (AD) progression. Ras-associated GTP-binding protein 7 (Rab7) is pivotal in autophagosome maturation and their fusi...

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Bibliographic Details
Main Authors: Yangyang Wang, Siyu Li, Xiao Liang, Jianing Fan, Shijie Li, Fanlin Zhou, Xiaoju Li, Mengmeng Lai, Dianmao Feng, Yu Li
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
AP2A1
Autophagy
Autophagosome
Axonal retrograde transport
Rab7
Online Access:https://doi.org/10.1186/s13195-025-01771-1
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https://doi.org/10.1186/s13195-025-01771-1

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