Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models

Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models

Abstract The epithelial and mesenchymal features of colorectal adenocarcinoma (CRAC) cell lines were compared in two-dimensional (2D) and three-dimensional (3D) cultures. In 2D cultures, the three CRAC cell lines exhibited epithelial characteristics with high E-cadherin and low vimentin levels, wher...

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Main Authors: Seiichi Shinji, Yutaro Ogawa, Takeshi Yamada, Akihisa Matsuda, Kay Uehara, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Toshimitsu Miyasaka, Shintaro Kanaka, Koki Hayashi, Yuuki Shichi, Masakazu Fujiwara, Kimimasa Takahashi, Tomio Arai, Toshiyuki Ishiwata, Hiroshi Yoshida
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Colorectal adenocarcinoma
2-dimensional culture
3-dimensional culture
Sphere
Scanning electron microscopy
Transmission electron microscopy
Online Access:https://doi.org/10.1038/s41598-025-87660-x
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https://doi.org/10.1038/s41598-025-87660-x

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