Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor
Follicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle cells featuring large nucleoli in a whorled pattern are usually seen. FDCS is...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/2648123 |
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| _version_ | 1832546128792387584 |
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| author | Madison Mograbi Michael S. Stump David T. Luyimbazi Mohammad H. Shakhatreh Douglas J. Grider |
| author_facet | Madison Mograbi Michael S. Stump David T. Luyimbazi Mohammad H. Shakhatreh Douglas J. Grider |
| author_sort | Madison Mograbi |
| collection | DOAJ |
| description | Follicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle cells featuring large nucleoli in a whorled pattern are usually seen. FDCS is classically found in cervical and axillary lymph nodes, with occasional involvement of extranodal sites. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is an uncommon subcategory of this neoplasm, demonstratively linked to the Epstein-Barr virus (EBV). This neoplasm can present similarly to FDCS, but systemic symptoms may be seen. Although, often found in the spleen and occasionally the liver, IPT-like FDCT has not previously been described within the pancreas. Presented, is an IPT-like FDCT of the pancreas and spleen of a 70 years old woman. Histologic features include variably sized geographic suppurative granulomas with chronic inflammatory cells and an atypical spindle cell proliferation with prominent nucleoli. Positivity for CD45 and CD68 in the larger spindled cells points to an inflammatory pseudotumor subtype and co-expression of CD21, CD23, and CD35 were indicative of follicular dendritic differentiation. The pseudotumor additionally demonstrated EBV-encoded RNA (EBER) positivity typical of IPT-like FDCT. Differentiation between inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) is additionally discussed. |
| format | Article |
| id | doaj-art-4c0715e9ba5f41ac90a163f9f408067a |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-4c0715e9ba5f41ac90a163f9f408067a2025-02-03T07:23:50ZengWileyCase Reports in Pathology2090-67812090-679X2019-01-01201910.1155/2019/26481232648123Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell TumorMadison Mograbi0Michael S. Stump1David T. Luyimbazi2Mohammad H. Shakhatreh3Douglas J. Grider4Eastern Virginia Medical School, Norfolk, VA, USADepartment of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA, USADepartment of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA, USAGastroenterology Division, Department of Medicine, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA, USADepartment of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA, USAFollicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle cells featuring large nucleoli in a whorled pattern are usually seen. FDCS is classically found in cervical and axillary lymph nodes, with occasional involvement of extranodal sites. Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) is an uncommon subcategory of this neoplasm, demonstratively linked to the Epstein-Barr virus (EBV). This neoplasm can present similarly to FDCS, but systemic symptoms may be seen. Although, often found in the spleen and occasionally the liver, IPT-like FDCT has not previously been described within the pancreas. Presented, is an IPT-like FDCT of the pancreas and spleen of a 70 years old woman. Histologic features include variably sized geographic suppurative granulomas with chronic inflammatory cells and an atypical spindle cell proliferation with prominent nucleoli. Positivity for CD45 and CD68 in the larger spindled cells points to an inflammatory pseudotumor subtype and co-expression of CD21, CD23, and CD35 were indicative of follicular dendritic differentiation. The pseudotumor additionally demonstrated EBV-encoded RNA (EBER) positivity typical of IPT-like FDCT. Differentiation between inflammatory pseudotumor (IPT) and inflammatory myofibroblastic tumor (IMT) is additionally discussed.http://dx.doi.org/10.1155/2019/2648123 |
| spellingShingle | Madison Mograbi Michael S. Stump David T. Luyimbazi Mohammad H. Shakhatreh Douglas J. Grider Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor Case Reports in Pathology |
| title | Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor |
| title_full | Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor |
| title_fullStr | Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor |
| title_full_unstemmed | Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor |
| title_short | Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor |
| title_sort | pancreatic inflammatory pseudotumor like follicular dendritic cell tumor |
| url | http://dx.doi.org/10.1155/2019/2648123 |
| work_keys_str_mv | AT madisonmograbi pancreaticinflammatorypseudotumorlikefolliculardendriticcelltumor AT michaelsstump pancreaticinflammatorypseudotumorlikefolliculardendriticcelltumor AT davidtluyimbazi pancreaticinflammatorypseudotumorlikefolliculardendriticcelltumor AT mohammadhshakhatreh pancreaticinflammatorypseudotumorlikefolliculardendriticcelltumor AT douglasjgrider pancreaticinflammatorypseudotumorlikefolliculardendriticcelltumor |