Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy
Chemical and physical quality attributes of herbal extract powders play an important role in the research and development of Chinese medicine preparations. The active pharmaceutical ingredients have a direct impact on the herbal extract’s efficacy, while the physical properties of raw material affec...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/704940 |
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| _version_ | 1832550349537280000 |
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| author | Gan Luo Bing Xu Xinyuan Shi Jianyu Li Shengyun Dai Yanjiang Qiao |
| author_facet | Gan Luo Bing Xu Xinyuan Shi Jianyu Li Shengyun Dai Yanjiang Qiao |
| author_sort | Gan Luo |
| collection | DOAJ |
| description | Chemical and physical quality attributes of herbal extract powders play an important role in the research and development of Chinese medicine preparations. The active pharmaceutical ingredients have a direct impact on the herbal extract’s efficacy, while the physical properties of raw material affect the pharmaceutical manufacturing process and the final products’ quality. In this study, tanshinone extract powders from Salvia miltiorrhiza which are widely used for the treatment of cardiovascular diseases in the clinic are taken as the research object. Both the chemical information and physical information of tanshinone extract powders are analyzed by near infrared (NIR) spectroscopy. The partial least squares (PLS) and least square support vector machine (LS-SVM) models are investigated to build the relationship between NIR spectra and reference values. PLS models performed well for the content of crytotanshinone, tanshinone IIA, the moisture, and average median particle size, while, for specific surface area and tapped density, the LS-SVM models performed better than the PLS models. Results demonstrated NIR to be a valid and fast process analytical technology tool to simultaneously determine multiple quality attributes of herbal extract powders and indicated that there existed some nonlinear relationship between NIR spectra and physical quality attributes. |
| format | Article |
| id | doaj-art-4bec3a3573f44cefbb13f5affd91b752 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-4bec3a3573f44cefbb13f5affd91b7522025-02-03T06:07:03ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792015-01-01201510.1155/2015/704940704940Rapid Characterization of Tanshinone Extract Powder by Near Infrared SpectroscopyGan Luo0Bing Xu1Xinyuan Shi2Jianyu Li3Shengyun Dai4Yanjiang Qiao5Beijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaChemical and physical quality attributes of herbal extract powders play an important role in the research and development of Chinese medicine preparations. The active pharmaceutical ingredients have a direct impact on the herbal extract’s efficacy, while the physical properties of raw material affect the pharmaceutical manufacturing process and the final products’ quality. In this study, tanshinone extract powders from Salvia miltiorrhiza which are widely used for the treatment of cardiovascular diseases in the clinic are taken as the research object. Both the chemical information and physical information of tanshinone extract powders are analyzed by near infrared (NIR) spectroscopy. The partial least squares (PLS) and least square support vector machine (LS-SVM) models are investigated to build the relationship between NIR spectra and reference values. PLS models performed well for the content of crytotanshinone, tanshinone IIA, the moisture, and average median particle size, while, for specific surface area and tapped density, the LS-SVM models performed better than the PLS models. Results demonstrated NIR to be a valid and fast process analytical technology tool to simultaneously determine multiple quality attributes of herbal extract powders and indicated that there existed some nonlinear relationship between NIR spectra and physical quality attributes.http://dx.doi.org/10.1155/2015/704940 |
| spellingShingle | Gan Luo Bing Xu Xinyuan Shi Jianyu Li Shengyun Dai Yanjiang Qiao Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy International Journal of Analytical Chemistry |
| title | Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy |
| title_full | Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy |
| title_fullStr | Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy |
| title_full_unstemmed | Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy |
| title_short | Rapid Characterization of Tanshinone Extract Powder by Near Infrared Spectroscopy |
| title_sort | rapid characterization of tanshinone extract powder by near infrared spectroscopy |
| url | http://dx.doi.org/10.1155/2015/704940 |
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