Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates
Objective. Identification of the weight and postmenstrual age (PMA) at successful weaning of NCPAP in preterm neonates and the factors influencing the successful wean. Study Design. Retrospective review of 454 neonates ≤32 weeks of gestational age (GA) who were placed on NCPAP and successfully weane...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/416073 |
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| author | Shantanu Rastogi Hariprem Rajasekhar Anju Gupta Alok Bhutada Deepa Rastogi Jen-Tien Wung |
| author_facet | Shantanu Rastogi Hariprem Rajasekhar Anju Gupta Alok Bhutada Deepa Rastogi Jen-Tien Wung |
| author_sort | Shantanu Rastogi |
| collection | DOAJ |
| description | Objective. Identification of the weight and postmenstrual age (PMA) at successful weaning of NCPAP in preterm neonates and the factors influencing the successful wean. Study Design. Retrospective review of 454 neonates ≤32 weeks of gestational age (GA) who were placed on NCPAP and successfully weaned to room air was performed. Results. Neonates had a mean birth weight (BW) of 1357±392 grams with a mean GA of 29.3±2.2 weeks. Neonates were weaned off NCPAP at mean weight of 1611±432 grams and mean PMA of 32.9±2.4 weeks. Univariate analysis showed that chorioamnionitis, intubation, surfactant use, PDA, sepsis/NEC, anemia, apnea, GER and IVH were significantly associated with the time to NCPAP wean. On multivariate analysis, among neonates that were intubated, BW was the only significant factor (𝑃<0.001) that was inversely related to time to successful NCPAP wean. Amongst non-intubated neonates, along with BW (𝑃<0.01), chorioamnionitis (𝑃<0.01), anemia (𝑃<0.0001), and GER (𝑃<0.02) played a significant role in weaning from NCPAP. Conclusion. Neonates were weaned off NCPAP at mean weight of 1611±432 grams and mean PMA of 32.9±2.4 weeks. BW significantly affects weaning among intubated and non-intubated neonates, though in neonates who were never intubated chorioamnionitis, anemia and GER also significantly affected the duration on NCPAP. |
| format | Article |
| id | doaj-art-4be4475449e6487a836b4036a5df99dd |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-4be4475449e6487a836b4036a5df99dd2025-02-03T01:02:31ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/416073416073Factors Affecting the Weaning from Nasal CPAP in Preterm NeonatesShantanu Rastogi0Hariprem Rajasekhar1Anju Gupta2Alok Bhutada3Deepa Rastogi4Jen-Tien Wung5Division of Neonatology, Maimonides Infants Children Hospital of Brooklyn, 1048 Tenth Avenue, G-103, Brooklyn, NY 11203, USADivision of Neonatology, Maimonides Infants Children Hospital of Brooklyn, 1048 Tenth Avenue, G-103, Brooklyn, NY 11203, USADivision of Neonatology, Maimonides Infants Children Hospital of Brooklyn, 1048 Tenth Avenue, G-103, Brooklyn, NY 11203, USADivision of Neonatology, Maimonides Infants Children Hospital of Brooklyn, 1048 Tenth Avenue, G-103, Brooklyn, NY 11203, USADivision of Respiratory and Sleep Medicine, Children's Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Avenue, Bronx, NY 10467, USADivision of Neonatology, Morgan Stanley Children's Hospital of New York, College of Physicians and Surgeons, Columbia University, Broadway, NY 10032, USAObjective. Identification of the weight and postmenstrual age (PMA) at successful weaning of NCPAP in preterm neonates and the factors influencing the successful wean. Study Design. Retrospective review of 454 neonates ≤32 weeks of gestational age (GA) who were placed on NCPAP and successfully weaned to room air was performed. Results. Neonates had a mean birth weight (BW) of 1357±392 grams with a mean GA of 29.3±2.2 weeks. Neonates were weaned off NCPAP at mean weight of 1611±432 grams and mean PMA of 32.9±2.4 weeks. Univariate analysis showed that chorioamnionitis, intubation, surfactant use, PDA, sepsis/NEC, anemia, apnea, GER and IVH were significantly associated with the time to NCPAP wean. On multivariate analysis, among neonates that were intubated, BW was the only significant factor (𝑃<0.001) that was inversely related to time to successful NCPAP wean. Amongst non-intubated neonates, along with BW (𝑃<0.01), chorioamnionitis (𝑃<0.01), anemia (𝑃<0.0001), and GER (𝑃<0.02) played a significant role in weaning from NCPAP. Conclusion. Neonates were weaned off NCPAP at mean weight of 1611±432 grams and mean PMA of 32.9±2.4 weeks. BW significantly affects weaning among intubated and non-intubated neonates, though in neonates who were never intubated chorioamnionitis, anemia and GER also significantly affected the duration on NCPAP.http://dx.doi.org/10.1155/2012/416073 |
| spellingShingle | Shantanu Rastogi Hariprem Rajasekhar Anju Gupta Alok Bhutada Deepa Rastogi Jen-Tien Wung Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates International Journal of Pediatrics |
| title | Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates |
| title_full | Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates |
| title_fullStr | Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates |
| title_full_unstemmed | Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates |
| title_short | Factors Affecting the Weaning from Nasal CPAP in Preterm Neonates |
| title_sort | factors affecting the weaning from nasal cpap in preterm neonates |
| url | http://dx.doi.org/10.1155/2012/416073 |
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