Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis

Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis

IntroductionPrimary Sjögren syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells into the salivary glands. The re-establishment of salivary glands (SGs) function in pSS remains a clinical challenge. Myeloid-derived growth factor (MYDGF) has anti-i...

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Bibliographic Details
Main Authors: Zi Yang, Mangnan Liu, Zhichao Chang, Conglin Du, Yang Yang, Chen Zhang, Liang Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
Sjögren’s syndrome
salivary glands
myeloid-derived growth factor
M2 macrophage polarization
CX3CL1
CX3CR1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465938/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465938/full

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