Colorectal cancer patient outcome is influenced by tumour-adherent bacteria through epigenetic regulation of cardinal genes including PHLPP1

Colorectal cancer patient outcome is influenced by tumour-adherent bacteria through epigenetic regulation of cardinal genes including PHLPP1

Objective How tumour-adherent microbiome can influence outcomes in patients with colorectal cancer (CRC).Methods and analysis CRC tissues (n=97) were analysed using RNAseq, whole exome sequencing (WES) and 16 r sRNA sequencing. Inflammatory/immune cells were quantified by immunohistochemistry in mic...

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Main Authors: Mathias Chamaillard, Khashayarsha Khazaie, Cécile Charpy, Iradj Sobhani, Aurelien Amiot, Nilmara De Oliveiro Alves, Emma Bergsten, Caroline Barau, Amaury Vaysse, Shatha Awaad, Mohammad Sadeghi, Denis Mestivier
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:BMJ Oncology
Online Access:https://bmjoncology.bmj.com/content/4/1/e000859.full
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