4-BENZOYLPYRIDINE OXIME DERIVATIVE (GIZH-298) VERSUS VALPROIC ACID: THE ANTICONVULSANT POTENTIAL EFFECT IN A MODEL OF EPILEPSY IN RATS WITH COBALT-INDUCED LESIONS

4-BENZOYLPYRIDINE OXIME DERIVATIVE (GIZH-298) VERSUS VALPROIC ACID: THE ANTICONVULSANT POTENTIAL EFFECT IN A MODEL OF EPILEPSY IN RATS WITH COBALT-INDUCED LESIONS

Objective of the research is to evaluate the anticonvulsant effect of the new original compound GIZH-298 (4-benzoylpyridine oxime derivative) versus valproic acid (VPA) in a model of epilepsy in rats with cobalt-induced lesions.Materials and methods. Modeling of epileptic status was performed using...

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Bibliographic Details
Main Authors: I. O. Gaydukov, S. A. Litvinova, T. A. Voronina, L. N. Nerobkova, L. A. Zhmurenko, G. V. Mokrov, G. G. Avakyan, I. S. Kutepova
Format: Article
Language:Russian
Published: IRBIS LLC 2017-08-01
Series:Эпилепсия и пароксизмальные состояния
Subjects:
gizh-298
4-benzoylpyridine oxime derivative
epilepsy
valproic acid
status epilepticus
seizures
eeg
homocysteine thiolactone. cobalt-induced epilepsy
rats.
Online Access:https://www.epilepsia.su/jour/article/view/346
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