Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems

Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems

Abstract Non-small cell lung cancer (NSCLC) remains a major global health challenge, with limited therapeutic success due to drug resistance and the immunosuppressive tumor microenvironment (TME). This study explores a novel strategy to overcome acquired resistance to immunotherapy in phosphoinositi...

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Bibliographic Details
Main Authors: Xiangyuan Jin, Tanghesi Wuyun, Yu Zhang, Xiaohong Wang, Ling Zhao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Non-small cell lung cancer
Immunotherapy resistance
PI3K/AKT/mTOR pathway
Tumor-derived exosomes
Ginsenoside Rb1
Online Access:https://doi.org/10.1186/s12951-025-03456-1
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https://doi.org/10.1186/s12951-025-03456-1

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