Two Cases of γ-Heavy Chain Disease and a Review of the Literature
Gamma heavy chain disease (γ-HCD) is a rare lymphoproliferative disorder characterised by the production of a truncated immunoglobulin heavy chain. Fewer than 200 cases have been reported in the literature. In some cases, γ-HCD occurs with other lymphoid neoplasms. This study reports clinical, bioch...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/4832619 |
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| author | I. Ramasamy Z. Rudzki |
| author_facet | I. Ramasamy Z. Rudzki |
| author_sort | I. Ramasamy |
| collection | DOAJ |
| description | Gamma heavy chain disease (γ-HCD) is a rare lymphoproliferative disorder characterised by the production of a truncated immunoglobulin heavy chain. Fewer than 200 cases have been reported in the literature. In some cases, γ-HCD occurs with other lymphoid neoplasms. This study reports clinical, biochemical, haematological, and histological findings in two cases of γ-HCD. We describe newer biochemical diagnostic tools (HevyLite measurement, capillary electrophoresis, and immunotyping) that can aid in the characterisation of γ-HCD. The first case is an 88-year-old woman with γ-HCD. The second case is an 81-year-old woman who developed γ-HCD during treatment for Waldenstrom’s macroglobulinemia. In the second patient, histopathology identified a separate clone responsible for the secretion of the gamma heavy chain. Studies on the clonal evolution of the disease may provide insight into therapeutic implications and the genomic complexity of the disease. |
| format | Article |
| id | doaj-art-4b923b55cf6c43fb9f0849ecfd14556d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-4b923b55cf6c43fb9f0849ecfd14556d2025-02-03T06:01:44ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/48326194832619Two Cases of γ-Heavy Chain Disease and a Review of the LiteratureI. Ramasamy0Z. Rudzki1Department of Biochemistry, Worcester Royal Hospital, Worcester, UKHeart of England NHS Trust, Birmingham, UKGamma heavy chain disease (γ-HCD) is a rare lymphoproliferative disorder characterised by the production of a truncated immunoglobulin heavy chain. Fewer than 200 cases have been reported in the literature. In some cases, γ-HCD occurs with other lymphoid neoplasms. This study reports clinical, biochemical, haematological, and histological findings in two cases of γ-HCD. We describe newer biochemical diagnostic tools (HevyLite measurement, capillary electrophoresis, and immunotyping) that can aid in the characterisation of γ-HCD. The first case is an 88-year-old woman with γ-HCD. The second case is an 81-year-old woman who developed γ-HCD during treatment for Waldenstrom’s macroglobulinemia. In the second patient, histopathology identified a separate clone responsible for the secretion of the gamma heavy chain. Studies on the clonal evolution of the disease may provide insight into therapeutic implications and the genomic complexity of the disease.http://dx.doi.org/10.1155/2018/4832619 |
| spellingShingle | I. Ramasamy Z. Rudzki Two Cases of γ-Heavy Chain Disease and a Review of the Literature Case Reports in Hematology |
| title | Two Cases of γ-Heavy Chain Disease and a Review of the Literature |
| title_full | Two Cases of γ-Heavy Chain Disease and a Review of the Literature |
| title_fullStr | Two Cases of γ-Heavy Chain Disease and a Review of the Literature |
| title_full_unstemmed | Two Cases of γ-Heavy Chain Disease and a Review of the Literature |
| title_short | Two Cases of γ-Heavy Chain Disease and a Review of the Literature |
| title_sort | two cases of γ heavy chain disease and a review of the literature |
| url | http://dx.doi.org/10.1155/2018/4832619 |
| work_keys_str_mv | AT iramasamy twocasesofgheavychaindiseaseandareviewoftheliterature AT zrudzki twocasesofgheavychaindiseaseandareviewoftheliterature |