Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone
Primary lymphoma of bone (PLB) confined to the epiphysis has only been described in four other patients. Due to the rarity of this entity, diagnosis has often been delayed, leading to mismanagement with adverse clinical consequences. We report a fifth case of primary epiphyseal lymphoma of bone loca...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/4160925 |
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| _version_ | 1832564322691186688 |
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| author | Shachar Kenan Leonard Kahn Morris Edelman Arlene Redner Samuel Kenan |
| author_facet | Shachar Kenan Leonard Kahn Morris Edelman Arlene Redner Samuel Kenan |
| author_sort | Shachar Kenan |
| collection | DOAJ |
| description | Primary lymphoma of bone (PLB) confined to the epiphysis has only been described in four other patients. Due to the rarity of this entity, diagnosis has often been delayed, leading to mismanagement with adverse clinical consequences. We report a fifth case of primary epiphyseal lymphoma of bone located in the left distal medial femoral epiphysis of a 13-year-old boy. Radiographic and histologic features of PLB are discussed, along with a review of the literature and pitfalls of misdiagnosis. The patient initially presented with six months of progressive left knee pain with an associated loss of passive range of motion. Imaging revealed a mixed radiolucent lesion within the left distal medial femoral epiphysis with cortical breakthrough. A core biopsy was performed revealing a blue round cell tumor. Thanks to modern immunohistochemistry techniques, a diagnosis of primary lymphoma of bone was quickly made. The patient thus avoided further surgical intervention and received the appropriate treatment of chemotherapy, with subsequent rapid resolution of the lesion. This case highlights the necessity of including primary lymphoma of bone in all epiphyseal lesion differential diagnoses, especially in the pediatric patient population when aggressive radiographic features are present. |
| format | Article |
| id | doaj-art-4b91eaad88fc40bb8b3efbc94f3c8ca9 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-4b91eaad88fc40bb8b3efbc94f3c8ca92025-02-03T01:11:20ZengWileyCase Reports in Pathology2090-67812090-679X2018-01-01201810.1155/2018/41609254160925Epiphyseal Primary Diffuse Large B-Cell Lymphoma of BoneShachar Kenan0Leonard Kahn1Morris Edelman2Arlene Redner3Samuel Kenan4Orthopaedic Oncology Fellow, Department of Orthopaedics, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USAMusculoskeletal Pathology, Department of Pathology, Zucker/Hofstra North Shore Long Island Jewish, Northwell Health Medical Center, New Hyde Park, NY, USAMusculoskeletal Pathology, Department of Pathology, Zucker/Hofstra North Shore Long Island Jewish, Northwell Health Medical Center, New Hyde Park, NY, USADepartment of Pediatric Hematology/Oncology, Zucker/Hofstra North Shore Long Island Jewish, Northwell Health Medical Center, New Hyde Park, NY, USAProfessor, Department of Orthopaedics, Zucker/Hofstra North Shore Long Island Jewish, Northwell Health Medical Center, New Hyde Park, NY, USAPrimary lymphoma of bone (PLB) confined to the epiphysis has only been described in four other patients. Due to the rarity of this entity, diagnosis has often been delayed, leading to mismanagement with adverse clinical consequences. We report a fifth case of primary epiphyseal lymphoma of bone located in the left distal medial femoral epiphysis of a 13-year-old boy. Radiographic and histologic features of PLB are discussed, along with a review of the literature and pitfalls of misdiagnosis. The patient initially presented with six months of progressive left knee pain with an associated loss of passive range of motion. Imaging revealed a mixed radiolucent lesion within the left distal medial femoral epiphysis with cortical breakthrough. A core biopsy was performed revealing a blue round cell tumor. Thanks to modern immunohistochemistry techniques, a diagnosis of primary lymphoma of bone was quickly made. The patient thus avoided further surgical intervention and received the appropriate treatment of chemotherapy, with subsequent rapid resolution of the lesion. This case highlights the necessity of including primary lymphoma of bone in all epiphyseal lesion differential diagnoses, especially in the pediatric patient population when aggressive radiographic features are present.http://dx.doi.org/10.1155/2018/4160925 |
| spellingShingle | Shachar Kenan Leonard Kahn Morris Edelman Arlene Redner Samuel Kenan Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone Case Reports in Pathology |
| title | Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone |
| title_full | Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone |
| title_fullStr | Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone |
| title_full_unstemmed | Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone |
| title_short | Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone |
| title_sort | epiphyseal primary diffuse large b cell lymphoma of bone |
| url | http://dx.doi.org/10.1155/2018/4160925 |
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