Alterations in functional and structural connectivity in the 6-OHDA-induced Parkinsonian rat model

Alterations in functional and structural connectivity in the 6-OHDA-induced Parkinsonian rat model

IntroductionParkinson's Disease (PD), the second most common neurodegenerative disorder, is characterized by motor and non-motor symptoms linked to dopaminergic neuron degeneration. This study utilized the 6-hydroxydopamine (6-OHDA) rat model to replicate PD-like dopaminergic degeneration throu...

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Bibliographic Details
Main Authors: Shuyi Zhu, Maurizio Bergamino, Alberto Fuentes, Ivette M. Sandoval, David J. Marmion, Christopher Bishop, Fredric P. Manfredsson, Ashley M. Stokes
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson's disease
6-hydroxydopamine
functional connectivity
structural connectivity
functional magnetic resonance imaging
diffusion magnetic resonance imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1591215/full
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https://www.frontiersin.org/articles/10.3389/fnins.2025.1591215/full

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