BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling
Abstract Disuse osteoporosis, caused by mechanical unloading, is linked to dysregulated TGFβ and BMP signaling. This study explores their roles and evaluates BMP9 as a potential therapy. A hindlimb unloading (HLU) mouse model was used to assess bone changes and signaling alterations. In vitro, a Rot...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-025-00510-y |
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