ATP Supply from Cytosol to Mitochondria Is an Additional Role of Aerobic Glycolysis to Prevent Programmed Cell Death by Maintenance of Mitochondrial Membrane Potential

ATP Supply from Cytosol to Mitochondria Is an Additional Role of Aerobic Glycolysis to Prevent Programmed Cell Death by Maintenance of Mitochondrial Membrane Potential

Eukaryotic cells generate ATP primarily via oxidative and substrate-level phosphorylation. Despite the superior efficiency of oxidative phosphorylation, eukaryotic cells often use both pathways as aerobic glycolysis, even in the presence of oxygen. However, its role in cell survival remains poorly u...

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Main Authors: Akane Sawai, Takeo Taniguchi, Kohsuke Noguchi, Taisuke Seike, Nobuyuki Okahashi, Masak Takaine, Fumio Matsuda
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Metabolites
Subjects:
aerobic glycolysis
breast cancer cells
<i>Saccharomyces cerevisiae</i>
metabolic rewiring
mitochondrial membrane potential
reverse mode of H<sup>+</sup>/ATPase
Online Access:https://www.mdpi.com/2218-1989/15/7/461
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