Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8+CD69+ T cells

Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8+CD69+ T cells

Background Liver metastasis is highly aggressive and immune tolerant, and lacks effective treatment strategies. This study aimed to develop a neoantigen hydrogel vaccine (NPT-gels) with high clinical feasibility and further investigate its efficacy and antitumor molecular mechanisms in combination w...

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Main Authors: Huan Yang, Ming Wu, Yongyi Zeng, Geng Chen, Zhixiong Cai, Xiaolong Liu, Da Zhang, Xiuqing Dong, Shichuan Tang, Ruijing Tang, Kongying Lin, Jun Fu, Yutong Guo, Fangzhou Lin, Tingfeng Huang, Jie Kong, Xiaowei Yin, Aimin Ge, Qizhu Lin
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/12/e009543.full
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https://jitc.bmj.com/content/12/12/e009543.full

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