Cytokine signaling defects in primary atopic diseases—an updated review

Cytokine signaling defects in primary atopic diseases—an updated review

Primary atopic disorders (PADs) are monogenic conditions associated with severe, early-onset atopic diseases. Clinically, they often overlap with polygenic allergic conditions, making specialized laboratory testing necessary to distinguish them from polygenic atopy. Multisystem involvement, such as...

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Main Authors: Vaishali Thakur, Rakesh Kumar Pilania, Arunima Sharma, Saniya Sharma, Alfred Thomas Mario, Taru Goyal, Madhubala Sharma, Gayathri Coimbatore Vaitheeswaran, Pandiarajan Vignesh, Surjit Singh, Manpreet Dhaliwal, Amit Rawat
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Allergy
Subjects:
primary atopic disorders
monogenic allergic diseases
primary immunodeficiencies
inborn errors of immunity
allergy
atopy
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2025.1617714/full
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