Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle
We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-col...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2013/205878 |
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| _version_ | 1832553393161240576 |
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| author | Shijie Song Shuojing Song Chuanhai Cao Xiaoyang Lin Kunyu Li Vasyl Sava Juan Sanchez-Ramos |
| author_facet | Shijie Song Shuojing Song Chuanhai Cao Xiaoyang Lin Kunyu Li Vasyl Sava Juan Sanchez-Ramos |
| author_sort | Shijie Song |
| collection | DOAJ |
| description | We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders. |
| format | Article |
| id | doaj-art-4b3a43b5372b488ea63927edafc4421b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4b3a43b5372b488ea63927edafc4421b2025-02-03T05:54:06ZengWileyStem Cells International1687-966X1687-96782013-01-01201310.1155/2013/205878205878Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a MicroneedleShijie Song0Shuojing Song1Chuanhai Cao2Xiaoyang Lin3Kunyu Li4Vasyl Sava5Juan Sanchez-Ramos6Department of Neurology, University of South Florida, 13220 Laurel Drive, Tampa, FL 33612, USAFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USADepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USADepartment of Neurology, University of South Florida, 13220 Laurel Drive, Tampa, FL 33612, USADepartment of Neurology, University of South Florida, 13220 Laurel Drive, Tampa, FL 33612, USADepartment of Neurology, University of South Florida, 13220 Laurel Drive, Tampa, FL 33612, USAWe tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.http://dx.doi.org/10.1155/2013/205878 |
| spellingShingle | Shijie Song Shuojing Song Chuanhai Cao Xiaoyang Lin Kunyu Li Vasyl Sava Juan Sanchez-Ramos Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle Stem Cells International |
| title | Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle |
| title_full | Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle |
| title_fullStr | Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle |
| title_full_unstemmed | Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle |
| title_short | Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle |
| title_sort | hippocampal neurogenesis and the brain repair response to brief stereotaxic insertion of a microneedle |
| url | http://dx.doi.org/10.1155/2013/205878 |
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