The association between bone density of lumbar spines and different daily protein intake in different renal function
Background Low protein intake (LPI) has been suggested as a treatment for chronic kidney disease (CKD). However, protein intake is essential for bone health.Methods We studied the database of the National Health and Nutrition Examination Survey, 2005–2010. Basic variables, metabolic diseases, and bo...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2298080 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591092051083264 |
|---|---|
| author | Chia-Lin Lee Kun-Hui Chen Wei‑Ju Liu Ching-Hsien Chen Shang-Feng Tsai |
| author_facet | Chia-Lin Lee Kun-Hui Chen Wei‑Ju Liu Ching-Hsien Chen Shang-Feng Tsai |
| author_sort | Chia-Lin Lee |
| collection | DOAJ |
| description | Background Low protein intake (LPI) has been suggested as a treatment for chronic kidney disease (CKD). However, protein intake is essential for bone health.Methods We studied the database of the National Health and Nutrition Examination Survey, 2005–2010. Basic variables, metabolic diseases, and bone density of different femoral areas were stratified into four subgroups according to different protein intake (DPI) (that is, <0.8, 0.8–1.0, 1.0–1.2, and >1.2 g/kg/day).Results Significant differences were found among all lumbar area bone mineral density (BMD) and T-scores (p < 0.0001). There was an apparent trend between a decreasing BMD in the CKD groups with increasing DPI in all single lumbar spines (L1, L2, L3, and L4) and all L spines (L1-L4). Compared with DPI (0.8–1.0 g/day/kg), higher risks of osteoporosis were noticed in the subgroup of >1.2 g/day/kg over L2 (relative risk (RR)=1.326, 95% confidence interval (CI)=1.062–1.656), subgroup >1.2 g/day/kg over L3 (RR = 1.31, 95%CI = 1.057–1.622), subgroup <0.8 g/day/kg over L4 (RR = 1.276, 95%CI = 1.015–1.605), subgroup <0.8 g/day/kg over all L spines (RR = 11.275, 95%CI = 1.051–1.548), and subgroup >1.2 g/day/kg over all L spines (RR = 0.333, 95%CI = 1.098–1.618). However, a higher risk of osteoporosis was observed only in the non-CKD group. There was an apparent trend of higher DPI coexisting with lower BMD and T scores in patients with CKD. For osteoporosis (reference:0.8–1.0 g/day/kg), lower (<0.8 g/day/kg) or higher DPI (>1.2 g/day/kg) was associated with higher risks in the non-CKD group, but not in the CKD group.Conclusions In the CKD group, LPI for renal protection was safe without threatening L spine bone density and without causing a higher risk of osteoporosis. |
| format | Article |
| id | doaj-art-4b363d0d5ab44f3c8d9096f6c46db925 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-4b363d0d5ab44f3c8d9096f6c46db9252025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2298080The association between bone density of lumbar spines and different daily protein intake in different renal functionChia-Lin Lee0Kun-Hui Chen1Wei‑Ju Liu2Ching-Hsien Chen3Shang-Feng Tsai4Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanIntelligent data mining laboratory, Department of Medical Research, Taichung Veterans General Hospital, Taichung, TaiwanDivisions of Nephrology and Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California at Davis, Davis, CA, USADepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, TaiwanBackground Low protein intake (LPI) has been suggested as a treatment for chronic kidney disease (CKD). However, protein intake is essential for bone health.Methods We studied the database of the National Health and Nutrition Examination Survey, 2005–2010. Basic variables, metabolic diseases, and bone density of different femoral areas were stratified into four subgroups according to different protein intake (DPI) (that is, <0.8, 0.8–1.0, 1.0–1.2, and >1.2 g/kg/day).Results Significant differences were found among all lumbar area bone mineral density (BMD) and T-scores (p < 0.0001). There was an apparent trend between a decreasing BMD in the CKD groups with increasing DPI in all single lumbar spines (L1, L2, L3, and L4) and all L spines (L1-L4). Compared with DPI (0.8–1.0 g/day/kg), higher risks of osteoporosis were noticed in the subgroup of >1.2 g/day/kg over L2 (relative risk (RR)=1.326, 95% confidence interval (CI)=1.062–1.656), subgroup >1.2 g/day/kg over L3 (RR = 1.31, 95%CI = 1.057–1.622), subgroup <0.8 g/day/kg over L4 (RR = 1.276, 95%CI = 1.015–1.605), subgroup <0.8 g/day/kg over all L spines (RR = 11.275, 95%CI = 1.051–1.548), and subgroup >1.2 g/day/kg over all L spines (RR = 0.333, 95%CI = 1.098–1.618). However, a higher risk of osteoporosis was observed only in the non-CKD group. There was an apparent trend of higher DPI coexisting with lower BMD and T scores in patients with CKD. For osteoporosis (reference:0.8–1.0 g/day/kg), lower (<0.8 g/day/kg) or higher DPI (>1.2 g/day/kg) was associated with higher risks in the non-CKD group, but not in the CKD group.Conclusions In the CKD group, LPI for renal protection was safe without threatening L spine bone density and without causing a higher risk of osteoporosis.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2298080Bone densitylumbar spinechronic kidney diseaseprotein dietosteoporosis |
| spellingShingle | Chia-Lin Lee Kun-Hui Chen Wei‑Ju Liu Ching-Hsien Chen Shang-Feng Tsai The association between bone density of lumbar spines and different daily protein intake in different renal function Renal Failure Bone density lumbar spine chronic kidney disease protein diet osteoporosis |
| title | The association between bone density of lumbar spines and different daily protein intake in different renal function |
| title_full | The association between bone density of lumbar spines and different daily protein intake in different renal function |
| title_fullStr | The association between bone density of lumbar spines and different daily protein intake in different renal function |
| title_full_unstemmed | The association between bone density of lumbar spines and different daily protein intake in different renal function |
| title_short | The association between bone density of lumbar spines and different daily protein intake in different renal function |
| title_sort | association between bone density of lumbar spines and different daily protein intake in different renal function |
| topic | Bone density lumbar spine chronic kidney disease protein diet osteoporosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2298080 |
| work_keys_str_mv | AT chialinlee theassociationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT kunhuichen theassociationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT weijuliu theassociationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT chinghsienchen theassociationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT shangfengtsai theassociationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT chialinlee associationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT kunhuichen associationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT weijuliu associationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT chinghsienchen associationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction AT shangfengtsai associationbetweenbonedensityoflumbarspinesanddifferentdailyproteinintakeindifferentrenalfunction |