The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021
Abstract Prostate cancer ranks among the most prevalent malignancies affecting males globally. This study sought to document the incidence, deaths and disability-adjusted life-years (DALYs) that were due to prostate cancer in the Middle East and North Africa (MENA) region, and its 21 countries, from...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83840-3 |
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| author | Saeid Safiri Ali Shamekh Kamaleddin Hassanzadeh Asra Fazlollahi Mark J. M. Sullman Mortaza Raeisi Ali-Asghar Kolahi |
| author_facet | Saeid Safiri Ali Shamekh Kamaleddin Hassanzadeh Asra Fazlollahi Mark J. M. Sullman Mortaza Raeisi Ali-Asghar Kolahi |
| author_sort | Saeid Safiri |
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| description | Abstract Prostate cancer ranks among the most prevalent malignancies affecting males globally. This study sought to document the incidence, deaths and disability-adjusted life-years (DALYs) that were due to prostate cancer in the Middle East and North Africa (MENA) region, and its 21 countries, from 1990 to 2021. We analysed publicly accessible data from the Global Burden of Disease 2021 study to present findings on the incidence, deaths, and disability-adjusted life years (DALYs) associated with prostate cancer. These metrics were reported as counts and age-standardised rates, each accompanied by 95% uncertainty intervals. In 2021, the age-standardised incidence of prostate cancer in the region was 27.4 per 100,000 population, representing a 125.1% increase from 1990. The age-standardised mortality rate was 10.1, and the age-standardised DALY rate was 173.6, neither of which showed significant increases since 1990. Qatar recorded the highest age-standardised DALY rate in 2021, while Algeria had the lowest. The largest number of incident cases, deaths, and DALYs in 2021 were found in the 65–69, 80–84, and 70–74 age groups, respectively. Additionally, from 1990 to 2021, the burden of prostate cancer largely increased with the socio-demographic index (SDI) at the regional level. The burden of prostate cancer in the MENA region rose markedly between 1990 and 2021. Further studies into the underlying causes of this increasing incidence are essential to devise effective strategies for the early detection and prevention of the disease. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-4b19005ff1cf4f959554a42576d32fe52025-01-19T12:18:09ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-83840-3The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021Saeid Safiri0Ali Shamekh1Kamaleddin Hassanzadeh2Asra Fazlollahi3Mark J. M. Sullman4Mortaza Raeisi5Ali-Asghar Kolahi6Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical SciencesSocial Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Urology, Faculty of Medicine, Tabriz University of Medical SciencesAging Research Institute, Tabriz University of Medical SciencesDepartment of Life and Health Sciences, University of NicosiaHematology and Oncology Research Center, Tabriz University of Medical SciencesSocial Determinants of Health Research Center, Shahid Beheshti University of Medical SciencesAbstract Prostate cancer ranks among the most prevalent malignancies affecting males globally. This study sought to document the incidence, deaths and disability-adjusted life-years (DALYs) that were due to prostate cancer in the Middle East and North Africa (MENA) region, and its 21 countries, from 1990 to 2021. We analysed publicly accessible data from the Global Burden of Disease 2021 study to present findings on the incidence, deaths, and disability-adjusted life years (DALYs) associated with prostate cancer. These metrics were reported as counts and age-standardised rates, each accompanied by 95% uncertainty intervals. In 2021, the age-standardised incidence of prostate cancer in the region was 27.4 per 100,000 population, representing a 125.1% increase from 1990. The age-standardised mortality rate was 10.1, and the age-standardised DALY rate was 173.6, neither of which showed significant increases since 1990. Qatar recorded the highest age-standardised DALY rate in 2021, while Algeria had the lowest. The largest number of incident cases, deaths, and DALYs in 2021 were found in the 65–69, 80–84, and 70–74 age groups, respectively. Additionally, from 1990 to 2021, the burden of prostate cancer largely increased with the socio-demographic index (SDI) at the regional level. The burden of prostate cancer in the MENA region rose markedly between 1990 and 2021. Further studies into the underlying causes of this increasing incidence are essential to devise effective strategies for the early detection and prevention of the disease.https://doi.org/10.1038/s41598-024-83840-3Prostate CancerMiddle East and North AfricaEpidemiologyMortalityDisease burdenIncidence |
| spellingShingle | Saeid Safiri Ali Shamekh Kamaleddin Hassanzadeh Asra Fazlollahi Mark J. M. Sullman Mortaza Raeisi Ali-Asghar Kolahi The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 Scientific Reports Prostate Cancer Middle East and North Africa Epidemiology Mortality Disease burden Incidence |
| title | The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 |
| title_full | The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 |
| title_fullStr | The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 |
| title_full_unstemmed | The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 |
| title_short | The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 |
| title_sort | burden of prostate cancer in the north africa and middle east region from 1990 to 2021 |
| topic | Prostate Cancer Middle East and North Africa Epidemiology Mortality Disease burden Incidence |
| url | https://doi.org/10.1038/s41598-024-83840-3 |
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