Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics
Aim. Chronic gastritis was assessed serologically, endoscopically and histologically to identify correlations between these methods. Methods. Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. Endosc...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/631461 |
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| author | Toshitatsu Takao Takeshi Ishikawa Takashi Ando Madoka Takao Tsuguhiro Matsumoto Yutaka Isozaki Mika Okita Yasuyuki Nagao Hirokazu Oyamada Keiichi Yokoyama Atsushi Tatebe Kazuhiko Uchiyama Osamu Handa Tomohisa Takagi Nobuaki Yagi Satoshi Kokura Yuji Naito Toshikazu Yoshikawa |
| author_facet | Toshitatsu Takao Takeshi Ishikawa Takashi Ando Madoka Takao Tsuguhiro Matsumoto Yutaka Isozaki Mika Okita Yasuyuki Nagao Hirokazu Oyamada Keiichi Yokoyama Atsushi Tatebe Kazuhiko Uchiyama Osamu Handa Tomohisa Takagi Nobuaki Yagi Satoshi Kokura Yuji Naito Toshikazu Yoshikawa |
| author_sort | Toshitatsu Takao |
| collection | DOAJ |
| description | Aim. Chronic gastritis was assessed serologically, endoscopically and histologically to identify correlations between these methods. Methods. Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. Endoscopic gastritis and histological gastritis were assessed and scored according to the Kimura-Takemoto classification system and the updated Sydney classification system respectively, and correlations between these three methods were studied. Results. Pepsinogen I/II ratio showed a significant correlation to the extent of mononuclear cell infiltration of the gastric corpus. When histological gastritis was divided, on the basis of the distribution of mononuclear cell infiltration, into gastritis limited to the antrum and corpus gastritis, these types were distinguished with high accuracy using a pepsinogen I/II ratio of 3 as the cutoff. A good correlation was also seen between pepsinogen I/II ratio and development of atrophy in endoscopic gastritis, where groups with and without advanced atrophy were also distinguished with high accuracy using a cutoff value of 3. Conclusion. Significant correlations exist between serum pepsinogen levels, endoscopic gastritis, and histological gastritis. Pepsinogen I/II ratio allows prediction of the existence of endoscopic gastritis and histological gastritis, or the extent of their development, with high accuracy. |
| format | Article |
| id | doaj-art-4ae3350eab3d407ebf0b4f4f24f8ba7e |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4ae3350eab3d407ebf0b4f4f24f8ba7e2025-02-03T01:21:56ZengWileyGastroenterology Research and Practice1687-61211687-630X2011-01-01201110.1155/2011/631461631461Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological DiagnosticsToshitatsu Takao0Takeshi Ishikawa1Takashi Ando2Madoka Takao3Tsuguhiro Matsumoto4Yutaka Isozaki5Mika Okita6Yasuyuki Nagao7Hirokazu Oyamada8Keiichi Yokoyama9Atsushi Tatebe10Kazuhiko Uchiyama11Osamu Handa12Tomohisa Takagi13Nobuaki Yagi14Satoshi Kokura15Yuji Naito16Toshikazu Yoshikawa17Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Gastroenterology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi city, Osaka 570-8540, JapanDepartment of Gastroenterology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi city, Osaka 570-8540, JapanDepartment of Gastroenterology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi city, Osaka 570-8540, JapanDepartment of Gastroenterology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi city, Osaka 570-8540, JapanDepartment of Pathology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi, Osaka 570-8540, JapanDepartment of Pathology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi, Osaka 570-8540, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, JapanAim. Chronic gastritis was assessed serologically, endoscopically and histologically to identify correlations between these methods. Methods. Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. Endoscopic gastritis and histological gastritis were assessed and scored according to the Kimura-Takemoto classification system and the updated Sydney classification system respectively, and correlations between these three methods were studied. Results. Pepsinogen I/II ratio showed a significant correlation to the extent of mononuclear cell infiltration of the gastric corpus. When histological gastritis was divided, on the basis of the distribution of mononuclear cell infiltration, into gastritis limited to the antrum and corpus gastritis, these types were distinguished with high accuracy using a pepsinogen I/II ratio of 3 as the cutoff. A good correlation was also seen between pepsinogen I/II ratio and development of atrophy in endoscopic gastritis, where groups with and without advanced atrophy were also distinguished with high accuracy using a cutoff value of 3. Conclusion. Significant correlations exist between serum pepsinogen levels, endoscopic gastritis, and histological gastritis. Pepsinogen I/II ratio allows prediction of the existence of endoscopic gastritis and histological gastritis, or the extent of their development, with high accuracy.http://dx.doi.org/10.1155/2011/631461 |
| spellingShingle | Toshitatsu Takao Takeshi Ishikawa Takashi Ando Madoka Takao Tsuguhiro Matsumoto Yutaka Isozaki Mika Okita Yasuyuki Nagao Hirokazu Oyamada Keiichi Yokoyama Atsushi Tatebe Kazuhiko Uchiyama Osamu Handa Tomohisa Takagi Nobuaki Yagi Satoshi Kokura Yuji Naito Toshikazu Yoshikawa Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics Gastroenterology Research and Practice |
| title | Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics |
| title_full | Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics |
| title_fullStr | Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics |
| title_full_unstemmed | Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics |
| title_short | Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics |
| title_sort | multifaceted assessment of chronic gastritis a study of correlations between serological endoscopic and histological diagnostics |
| url | http://dx.doi.org/10.1155/2011/631461 |
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