Multicellular Tumor Spheroids as an in Vivo–Like Tumor Model for Three-Dimensional Imaging of Chemotherapeutic and Nano Material Cellular Penetration

We present a flexible and highly reproducible method using three-dimensional (3D) multicellular tumor spheroids to quantify chemotherapeutic and nanoparticle penetration properties in vitro. We generated HeLa cell–derived spheroids using the liquid overlay method. To properly characterize HeLa spher...

Full description

Saved in:
Bibliographic Details
Main Authors: Hui-li Ma, Qiao Jiang, Siyuan Han, Yan Wu, Jin Cui Tomshine, Dongliang Wang, Yaling Gan, Guozhang Zou, Xing-Jie Liang
Format: Article
Language:English
Published: SAGE Publishing 2012-11-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2012.00012
Tags: Add Tag
No Tags, Be the first to tag this record!