Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35

Background Gut microbiota can significantly alter the risk or progression of cancer by maintaining gut immune system homeostasis. However, the exact mechanism by which the gut microbiota and its metabolites influence colorectal tumorigenesis is unclear.Methods The roles of tryptophan metabolite indo...

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Bibliographic Details
Main Authors: Juanjuan Wang, Yuan Zhang, Yang Hao, Chen Xu, Yazheng Yang, Rongcun Yang
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e011155.full
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