Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment
In the present study, the effect of aqueous extracts of saffron on morphine-induced memory impairment was investigated. On the training trial, the mice received an electric shock when the animals were entered into the dark compartment. Twenty-four and forty-eight hours later, the time latency for en...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2012/494367 |
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| author | Sayede Maryam Naghibi Mahmoud Hosseini Fatemeh Khani Motahare Rahimi Farzaneh Vafaee Hassan Rakhshandeh Azita Aghaie |
| author_facet | Sayede Maryam Naghibi Mahmoud Hosseini Fatemeh Khani Motahare Rahimi Farzaneh Vafaee Hassan Rakhshandeh Azita Aghaie |
| author_sort | Sayede Maryam Naghibi |
| collection | DOAJ |
| description | In the present study, the effect of aqueous extracts of saffron on morphine-induced memory impairment was investigated. On the training trial, the mice received an electric shock when the animals were entered into the dark compartment. Twenty-four and forty-eight hours later, the time latency for entering the dark compartment was recorded and defined as the retention trial. The mice were divided into (1) control, (2) morphine which received morphine before the training in the passive avoidance test, (3–5) three groups treated by 50, 150 and 450 mg/kg of saffron extract before the training trial, and (6 and 7) the two other groups received 150 and 450 mg/kg of saffron extract before the retention trial. The time latency in morphine-treated group was lower than control (P < 0.01). Treatment of the animals by 150 and 450 mg/kg of saffron extract before the training trial increased the time latency at 24 and 48 hours after the training trial (P < 0.05 and P < 0.01). Administration of both 150 and 450 mg/kg doses of the extract before retention trials also increased the time latency (P < 0.01). The results revealed that the saffron extract attenuated morphine-induced memory impairment. |
| format | Article |
| id | doaj-art-4ac201912c4c4fe0857cb5d91d2a5f62 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-4ac201912c4c4fe0857cb5d91d2a5f622025-02-03T05:49:42ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422012-01-01201210.1155/2012/494367494367Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory ImpairmentSayede Maryam Naghibi0Mahmoud Hosseini1Fatemeh Khani2Motahare Rahimi3Farzaneh Vafaee4Hassan Rakhshandeh5Azita Aghaie6Neuroscience Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeuroscience Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeuroscience Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeuroscience Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeuroscience Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPharmacological Research Center of Medicinal Plants and Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, IranPharmacological Research Center of Medicinal Plants and Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, IranIn the present study, the effect of aqueous extracts of saffron on morphine-induced memory impairment was investigated. On the training trial, the mice received an electric shock when the animals were entered into the dark compartment. Twenty-four and forty-eight hours later, the time latency for entering the dark compartment was recorded and defined as the retention trial. The mice were divided into (1) control, (2) morphine which received morphine before the training in the passive avoidance test, (3–5) three groups treated by 50, 150 and 450 mg/kg of saffron extract before the training trial, and (6 and 7) the two other groups received 150 and 450 mg/kg of saffron extract before the retention trial. The time latency in morphine-treated group was lower than control (P < 0.01). Treatment of the animals by 150 and 450 mg/kg of saffron extract before the training trial increased the time latency at 24 and 48 hours after the training trial (P < 0.05 and P < 0.01). Administration of both 150 and 450 mg/kg doses of the extract before retention trials also increased the time latency (P < 0.01). The results revealed that the saffron extract attenuated morphine-induced memory impairment.http://dx.doi.org/10.1155/2012/494367 |
| spellingShingle | Sayede Maryam Naghibi Mahmoud Hosseini Fatemeh Khani Motahare Rahimi Farzaneh Vafaee Hassan Rakhshandeh Azita Aghaie Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment Advances in Pharmacological Sciences |
| title | Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment |
| title_full | Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment |
| title_fullStr | Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment |
| title_full_unstemmed | Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment |
| title_short | Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment |
| title_sort | effect of aqueous extract of crocus sativus l on morphine induced memory impairment |
| url | http://dx.doi.org/10.1155/2012/494367 |
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