Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo
Professional mononuclear phagocytes such as polymorphonuclear neutrophils (PMN), monocytes, and macrophages are considered as the first line of defence against invasive pathogens. The formation of extracellular traps (ETs) by activated mononuclear phagocytes is meanwhile well accepted as an effector...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5898074 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550691888955392 |
|---|---|
| author | Liliana M. R. Silva Tamara Muñoz-Caro Rafael A. Burgos Maria A. Hidalgo Anja Taubert Carlos Hermosilla |
| author_facet | Liliana M. R. Silva Tamara Muñoz-Caro Rafael A. Burgos Maria A. Hidalgo Anja Taubert Carlos Hermosilla |
| author_sort | Liliana M. R. Silva |
| collection | DOAJ |
| description | Professional mononuclear phagocytes such as polymorphonuclear neutrophils (PMN), monocytes, and macrophages are considered as the first line of defence against invasive pathogens. The formation of extracellular traps (ETs) by activated mononuclear phagocytes is meanwhile well accepted as an effector mechanism of the early host innate immune response acting against microbial infections. Recent investigations showed evidence that ETosis is a widely spread effector mechanism in vertebrates and invertebrates being utilized to entrap and kill bacteria, fungi, viruses, and protozoan parasites. ETs are released in response to intact protozoan parasites or to parasite-specific antigens in a controlled cell death process. Released ETs consist of nuclear DNA as backbone adorned with histones, antimicrobial peptides, and phagocyte-specific granular enzymes thereby producing a sticky extracellular matrix capable of entrapping and killing pathogens. This review summarizes recent data on protozoa-induced ETosis. Special attention will be given to molecular mechanisms of protozoa-induced ETosis and on its consequences for the parasites successful reproduction and life cycle accomplishment. |
| format | Article |
| id | doaj-art-4aa68fedfee1405483054abdcdb8d2ce |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4aa68fedfee1405483054abdcdb8d2ce2025-02-03T06:06:02ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/58980745898074Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In VivoLiliana M. R. Silva0Tamara Muñoz-Caro1Rafael A. Burgos2Maria A. Hidalgo3Anja Taubert4Carlos Hermosilla5Institute of Parasitology, Justus Liebig University Giessen, 35392 Giessen, GermanyInstitute of Parasitology, Justus Liebig University Giessen, 35392 Giessen, GermanyLaboratory of Molecular Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, University Austral of Chile, Valdivia, ChileLaboratory of Molecular Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, University Austral of Chile, Valdivia, ChileInstitute of Parasitology, Justus Liebig University Giessen, 35392 Giessen, GermanyInstitute of Parasitology, Justus Liebig University Giessen, 35392 Giessen, GermanyProfessional mononuclear phagocytes such as polymorphonuclear neutrophils (PMN), monocytes, and macrophages are considered as the first line of defence against invasive pathogens. The formation of extracellular traps (ETs) by activated mononuclear phagocytes is meanwhile well accepted as an effector mechanism of the early host innate immune response acting against microbial infections. Recent investigations showed evidence that ETosis is a widely spread effector mechanism in vertebrates and invertebrates being utilized to entrap and kill bacteria, fungi, viruses, and protozoan parasites. ETs are released in response to intact protozoan parasites or to parasite-specific antigens in a controlled cell death process. Released ETs consist of nuclear DNA as backbone adorned with histones, antimicrobial peptides, and phagocyte-specific granular enzymes thereby producing a sticky extracellular matrix capable of entrapping and killing pathogens. This review summarizes recent data on protozoa-induced ETosis. Special attention will be given to molecular mechanisms of protozoa-induced ETosis and on its consequences for the parasites successful reproduction and life cycle accomplishment.http://dx.doi.org/10.1155/2016/5898074 |
| spellingShingle | Liliana M. R. Silva Tamara Muñoz-Caro Rafael A. Burgos Maria A. Hidalgo Anja Taubert Carlos Hermosilla Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo Mediators of Inflammation |
| title | Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo |
| title_full | Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo |
| title_fullStr | Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo |
| title_full_unstemmed | Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo |
| title_short | Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo |
| title_sort | far beyond phagocytosis phagocyte derived extracellular traps act efficiently against protozoan parasites in vitro and in vivo |
| url | http://dx.doi.org/10.1155/2016/5898074 |
| work_keys_str_mv | AT lilianamrsilva farbeyondphagocytosisphagocytederivedextracellulartrapsactefficientlyagainstprotozoanparasitesinvitroandinvivo AT tamaramunozcaro farbeyondphagocytosisphagocytederivedextracellulartrapsactefficientlyagainstprotozoanparasitesinvitroandinvivo AT rafaelaburgos farbeyondphagocytosisphagocytederivedextracellulartrapsactefficientlyagainstprotozoanparasitesinvitroandinvivo AT mariaahidalgo farbeyondphagocytosisphagocytederivedextracellulartrapsactefficientlyagainstprotozoanparasitesinvitroandinvivo AT anjataubert farbeyondphagocytosisphagocytederivedextracellulartrapsactefficientlyagainstprotozoanparasitesinvitroandinvivo AT carloshermosilla farbeyondphagocytosisphagocytederivedextracellulartrapsactefficientlyagainstprotozoanparasitesinvitroandinvivo |