Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving Bacillus subtilis

Biophysical modeling reveals the transcriptional regulatory mechanism of Spo0A, the master regulator in starving Bacillus subtilis

ABSTRACT In starving Bacillus subtilis bacteria, the initiation of two survival programs—biofilm formation and sporulation—is controlled by the same phosphorylated master regulator, Spo0A~P. Its gene, spo0A, is transcribed from two promoters, Pv and Ps, that are, respectively, regulated by RNA polym...

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Bibliographic Details
Main Authors: Yujia Zhang, Cristina S. D. Palma, Zhuo Chen, Brenda Zarazúa-Osorio, Masaya Fujita, Oleg A. Igoshin
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSystems
Subjects:
spo0A transcriptional regulation
0A boxes
biophysical model
Bacillus subtilis
Online Access:https://journals.asm.org/doi/10.1128/msystems.00072-25
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https://journals.asm.org/doi/10.1128/msystems.00072-25

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