Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects
Abstract This retrospective study investigated the risk of primary open-angle glaucoma (POAG) among individuals identified as glaucoma suspects and examined associated cardiovascular risk factors. We conducted a longitudinal, nationwide cohort study using data from the Korean National Health Insuran...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-85505-1 |
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| author | Kyoung In Jung Yong Chan Kim Hee Jong Shin Chan Kee Park |
| author_facet | Kyoung In Jung Yong Chan Kim Hee Jong Shin Chan Kee Park |
| author_sort | Kyoung In Jung |
| collection | DOAJ |
| description | Abstract This retrospective study investigated the risk of primary open-angle glaucoma (POAG) among individuals identified as glaucoma suspects and examined associated cardiovascular risk factors. We conducted a longitudinal, nationwide cohort study using data from the Korean National Health Insurance Service (KNHIS) and included 362,285 participants aged ≥ 40 years from the Korean National Health Screening Program (NHSP) without pre-existing POAG in 2009 and 2010. Of these, glaucoma suspects (n = 32,220) were defined as individuals with at least two recorded instances of the KCD code H400 for glaucoma suspect and no prior antiglaucoma medication prescriptions before health screening. The primary outcome was the diagnosis of POAG and the prescription of antiglaucoma medications. Over a 6-year follow-up, 4.92% of glaucoma suspects developed POAG. Through multivariate Cox regression analysis, glaucoma suspects with diabetes, hypertension, dyslipidemia, or coronary heart disease exhibited a greater risk of conversion to POAG than those without these comorbidities ([HR, 1.354; 95%CI, 1.201 to 1.527] for diabetes, [HR, 1.139; 95%CI, 1.019 to 1.273] for systemic hypertension, [HR, 1.128; 95%CI, 1.013 to 1.26] for dyslipidemia, [HR, 1.124, 95%CI, 1.007 to 1.254] for coronary heart disease).This nationwide study observed that among glaucoma suspects, having cardiovascular risk factors/disease was associated with higher risk of developing POAG. |
| format | Article |
| id | doaj-art-4a88aeee02cf41758ead2ca56b481eab |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-4a88aeee02cf41758ead2ca56b481eab2025-01-19T12:20:54ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-85505-1Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspectsKyoung In Jung0Yong Chan Kim1Hee Jong Shin2Chan Kee Park3Department of Ophthalmology, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, College of Medicine, The Catholic University of KoreaAbstract This retrospective study investigated the risk of primary open-angle glaucoma (POAG) among individuals identified as glaucoma suspects and examined associated cardiovascular risk factors. We conducted a longitudinal, nationwide cohort study using data from the Korean National Health Insurance Service (KNHIS) and included 362,285 participants aged ≥ 40 years from the Korean National Health Screening Program (NHSP) without pre-existing POAG in 2009 and 2010. Of these, glaucoma suspects (n = 32,220) were defined as individuals with at least two recorded instances of the KCD code H400 for glaucoma suspect and no prior antiglaucoma medication prescriptions before health screening. The primary outcome was the diagnosis of POAG and the prescription of antiglaucoma medications. Over a 6-year follow-up, 4.92% of glaucoma suspects developed POAG. Through multivariate Cox regression analysis, glaucoma suspects with diabetes, hypertension, dyslipidemia, or coronary heart disease exhibited a greater risk of conversion to POAG than those without these comorbidities ([HR, 1.354; 95%CI, 1.201 to 1.527] for diabetes, [HR, 1.139; 95%CI, 1.019 to 1.273] for systemic hypertension, [HR, 1.128; 95%CI, 1.013 to 1.26] for dyslipidemia, [HR, 1.124, 95%CI, 1.007 to 1.254] for coronary heart disease).This nationwide study observed that among glaucoma suspects, having cardiovascular risk factors/disease was associated with higher risk of developing POAG.https://doi.org/10.1038/s41598-025-85505-1 |
| spellingShingle | Kyoung In Jung Yong Chan Kim Hee Jong Shin Chan Kee Park Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects Scientific Reports |
| title | Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects |
| title_full | Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects |
| title_fullStr | Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects |
| title_full_unstemmed | Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects |
| title_short | Nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in Korean glaucoma suspects |
| title_sort | nationwide cohort study of primary open angle glaucoma risk and cardiovascular factors among in korean glaucoma suspects |
| url | https://doi.org/10.1038/s41598-025-85505-1 |
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