Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity
Biomarkers that capture treatment effects could improve the precision of clinical decision making for restorative therapies. We examined the performance of candidate structural, functional, and angiogenesis-related MRI biomarkers before and after a 3-week course of standardized robotic therapy in 18...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/9867196 |
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| author | Erin Burke Quinlan Lucy Dodakian Jill See Alison McKenzie Jill Campbell Stewart Steven C. Cramer |
| author_facet | Erin Burke Quinlan Lucy Dodakian Jill See Alison McKenzie Jill Campbell Stewart Steven C. Cramer |
| author_sort | Erin Burke Quinlan |
| collection | DOAJ |
| description | Biomarkers that capture treatment effects could improve the precision of clinical decision making for restorative therapies. We examined the performance of candidate structural, functional, and angiogenesis-related MRI biomarkers before and after a 3-week course of standardized robotic therapy in 18 patients with chronic stroke and hypothesized that results vary significantly according to stroke severity. Patients were 4.1 ± 1 months poststroke, with baseline arm Fugl-Meyer scores of 20–60. When all patients were examined together, no imaging measure changed over time in a manner that correlated with treatment-induced motor gains. However, when also considering the interaction with baseline motor status, treatment-induced motor gains were significantly related to change in three functional connectivity measures: ipsilesional motor cortex connectivity with (1) contralesional motor cortex (p=0.003), (2) contralesional dorsal premotor cortex (p=0.005), and (3) ipsilesional dorsal premotor cortex (p=0.004). In more impaired patients, larger treatment gains were associated with greater increases in functional connectivity, whereas in less impaired patients larger treatment gains were associated with greater decreases in functional connectivity. Functional connectivity measures performed best as biomarkers of treatment effects after stroke. The relationship between changes in functional connectivity and treatment gains varied according to baseline stroke severity. Biomarkers of restorative therapy effects are not one-size-fits-all after stroke. |
| format | Article |
| id | doaj-art-4a6ac4dbe6944b8d80d87445a08bac62 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-4a6ac4dbe6944b8d80d87445a08bac622025-02-03T05:59:48ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/98671969867196Biomarkers of Rehabilitation Therapy Vary according to Stroke SeverityErin Burke Quinlan0Lucy Dodakian1Jill See2Alison McKenzie3Jill Campbell Stewart4Steven C. Cramer5Department of Anatomy & Neurobiology, University of California, Irvine, CA, USADepartment of Neurology, University of California, Irvine, CA, USADepartment of Neurology, University of California, Irvine, CA, USADepartment of Physical Therapy, Chapman University, Orange, CA, USADepartment of Exercise Science, University of South Carolina, Columbia, SC, USADepartment of Anatomy & Neurobiology, University of California, Irvine, CA, USABiomarkers that capture treatment effects could improve the precision of clinical decision making for restorative therapies. We examined the performance of candidate structural, functional, and angiogenesis-related MRI biomarkers before and after a 3-week course of standardized robotic therapy in 18 patients with chronic stroke and hypothesized that results vary significantly according to stroke severity. Patients were 4.1 ± 1 months poststroke, with baseline arm Fugl-Meyer scores of 20–60. When all patients were examined together, no imaging measure changed over time in a manner that correlated with treatment-induced motor gains. However, when also considering the interaction with baseline motor status, treatment-induced motor gains were significantly related to change in three functional connectivity measures: ipsilesional motor cortex connectivity with (1) contralesional motor cortex (p=0.003), (2) contralesional dorsal premotor cortex (p=0.005), and (3) ipsilesional dorsal premotor cortex (p=0.004). In more impaired patients, larger treatment gains were associated with greater increases in functional connectivity, whereas in less impaired patients larger treatment gains were associated with greater decreases in functional connectivity. Functional connectivity measures performed best as biomarkers of treatment effects after stroke. The relationship between changes in functional connectivity and treatment gains varied according to baseline stroke severity. Biomarkers of restorative therapy effects are not one-size-fits-all after stroke.http://dx.doi.org/10.1155/2018/9867196 |
| spellingShingle | Erin Burke Quinlan Lucy Dodakian Jill See Alison McKenzie Jill Campbell Stewart Steven C. Cramer Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity Neural Plasticity |
| title | Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity |
| title_full | Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity |
| title_fullStr | Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity |
| title_full_unstemmed | Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity |
| title_short | Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity |
| title_sort | biomarkers of rehabilitation therapy vary according to stroke severity |
| url | http://dx.doi.org/10.1155/2018/9867196 |
| work_keys_str_mv | AT erinburkequinlan biomarkersofrehabilitationtherapyvaryaccordingtostrokeseverity AT lucydodakian biomarkersofrehabilitationtherapyvaryaccordingtostrokeseverity AT jillsee biomarkersofrehabilitationtherapyvaryaccordingtostrokeseverity AT alisonmckenzie biomarkersofrehabilitationtherapyvaryaccordingtostrokeseverity AT jillcampbellstewart biomarkersofrehabilitationtherapyvaryaccordingtostrokeseverity AT stevenccramer biomarkersofrehabilitationtherapyvaryaccordingtostrokeseverity |