FRMD8 inhibits tumor metastasis in BRCA1-associated TNBC by negatively regulating tmTNF-α

FRMD8 inhibits tumor metastasis in BRCA1-associated TNBC by negatively regulating tmTNF-α

Abstract Triple-negative breast cancer (TNBC), particularly in patients with metastasis, is associated with limited treatment options and shorter survival times. In this study, through library screening and animal experiments, we identified that the low expression of FERM domain-containing protein 8...

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Bibliographic Details
Main Authors: Jun Xu, Xiaoyu Yang, Peng Shu, Wei Wang, Haibo Wu, Zhe Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
FRMD8 (FERM domain-containing protein 8)
tmTNF-α (transmembrane TNF-α)
Breast cancer metastasis
NF-κB (nuclear factor kappa B) pathways
Online Access:https://doi.org/10.1186/s11658-025-00754-2
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https://doi.org/10.1186/s11658-025-00754-2

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