Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment

Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment

Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor involved in regulating cellular antioxidant defense and detoxification mechanisms. It mitigates oxidative stress and xenobiotic-induced damage by inducing the expression of cytoprotective enzymes, including HO-...

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Main Authors: Xinyi Yang, Yingchao Liu, Jinghao Cao, Cuiyun Wu, Lusheng Tang, Wenxia Bian, Yuhan Chen, Lingyan Yu, Yunyi Wu, Sainan Li, Yuhuan Shen, Jun Xia, Jing Du
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02491-z
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