SPINK6 inhibits human airway serine proteases and restricts influenza virus activation

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation

Abstract SPINK6 was identified in human skin as a cellular inhibitor of serine proteases of the KLK family. Airway serine proteases are required to cleave hemagglutinin (HA) of influenza A viruses (IAVs) to initiate an infection in the human airway. We hypothesized that SPINK6 may inhibit common air...

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Bibliographic Details
Main Authors: Dong Wang, Cun Li, Man Chun Chiu, Yifei Yu, Xiaojuan Liu, Xiaoyu Zhao, Jingjing Huang, Zhongshan Cheng, Shuofeng Yuan, Vincent Poon, Jian‐Piao Cai, Hin Chu, Jasper Fuk‐Woo Chan, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou
Format: Article
Language:English
Published: Springer Nature 2021-11-01
Series:EMBO Molecular Medicine
Subjects:
airway organoids
HA cleavage
influenza virus
SPINK6
virus maturation
Online Access:https://doi.org/10.15252/emmm.202114485
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https://doi.org/10.15252/emmm.202114485

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