Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies
Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated tha...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/971614 |
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| _version_ | 1832568070638403584 |
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| author | Marie-Noëlle Giraud Anne Géraldine Guex Hendrik T. Tevaearai |
| author_facet | Marie-Noëlle Giraud Anne Géraldine Guex Hendrik T. Tevaearai |
| author_sort | Marie-Noëlle Giraud |
| collection | DOAJ |
| description | Cell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the injection and their low survival in the hostile environment. It has indeed been demonstrated that cell mortality due to the injection approaches 90%. Major issues still need to be resolved and bed-to-bench followup is paramount to foster clinical implementations. The tissue engineering approach thus constitutes an attractive alternative since it provides the opportunity to deliver a large number of cells that are already organized in an extracellular matrix. Recent laboratory reports confirmed the interest of this approach and already encouraged a few groups to investigate it in clinical studies. We discuss current knowledge regarding engineered tissue for myocardial repair or replacement and in particular the recent implementation of nanotechnological approaches. |
| format | Article |
| id | doaj-art-4a12f362832843a8b4d0d72b96a0d6d8 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-4a12f362832843a8b4d0d72b96a0d6d82025-02-03T00:59:48ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/971614971614Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and NanotechnologiesMarie-Noëlle Giraud0Anne Géraldine Guex1Hendrik T. Tevaearai2Cardiology, Department of Medicine, Faculty of Science, University of Fribourg, Chemin du Musée 5, 1700 Fribourg, SwitzerlandClinic for Cardiovascular Surgery, Inselspital Berne, Berne University Hospital and University of Berne, SwitzerlandClinic for Cardiovascular Surgery, Inselspital Berne, Berne University Hospital and University of Berne, SwitzerlandCell therapies have gained increasing interest and developed in several approaches related to the treatment of damaged myocardium. The results of multiple clinical trials have already been reported, almost exclusively involving the direct injection of stem cells. It has, however, been postulated that the efficiency of injected cells could possibly be hindered by the mechanical trauma due to the injection and their low survival in the hostile environment. It has indeed been demonstrated that cell mortality due to the injection approaches 90%. Major issues still need to be resolved and bed-to-bench followup is paramount to foster clinical implementations. The tissue engineering approach thus constitutes an attractive alternative since it provides the opportunity to deliver a large number of cells that are already organized in an extracellular matrix. Recent laboratory reports confirmed the interest of this approach and already encouraged a few groups to investigate it in clinical studies. We discuss current knowledge regarding engineered tissue for myocardial repair or replacement and in particular the recent implementation of nanotechnological approaches.http://dx.doi.org/10.1155/2012/971614 |
| spellingShingle | Marie-Noëlle Giraud Anne Géraldine Guex Hendrik T. Tevaearai Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies Cardiology Research and Practice |
| title | Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies |
| title_full | Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies |
| title_fullStr | Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies |
| title_full_unstemmed | Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies |
| title_short | Cell Therapies for Heart Function Recovery: Focus on Myocardial Tissue Engineering and Nanotechnologies |
| title_sort | cell therapies for heart function recovery focus on myocardial tissue engineering and nanotechnologies |
| url | http://dx.doi.org/10.1155/2012/971614 |
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